PARKINSON'S DISEASE NEWS
26th September 2010 - New review
THE EFFECT OF STEM CELL SURGERY ON PARKINSON'S DISEASE
Stem cell surgery, in which stem cells are placed inside the brain in order to replace lost cells, is claimed to be necessary for Parkinson's Disease because it is assumed that there is massive loss of the dopaminergic neurons (the cells involved in Parkinson's Disease). However, the theoretical basis of stem cell surgery in Parkinson's Disease is based on a fallacy, because no studies have ever shown that there is a massive loss of the dopaminergic neurons in Parkinson's Disease. Parkinson's Disease results from the reduced activity of the existing cells. It is inevitable that any new cells will eventually function at the same insufficient rate as the existing cells, because their biochemical environment would be identical.
When stem cell surgery underwent formal clinical trials there was found to be little or no effect   . In a later study, a patient who underwent adult neural stem cell transplantation appeared to significantly reduce their symptoms, but after five years they had symptoms that were worse than when they started, and were deteriorating rapidly . In a subsequent study, involving the use of bone marrow derived mesenchymal stem cells, there was also little or no effect . Transplanted cells eventually cease to function normally anyway and still develop changes that are characteristic of Parkinson's Disease  , confirming that Parkinson's Disease is a biochemical state that can affect any cells - those that were already there and those that are placed there. In order to refer to this article on its own click here.
23rd September 2010 - New book
YOU NEVER MISS THE DOPAMINE.....(UNTIL THE BRAIN RUNS DRY)
Publisher's description : From the author of "No Doorway Wide Enough," "Undercover Trucker," and "Hunky Dunk," a real-life look at how one man deals with his Parkinson's disease decline by laughing at it. Told in a series of essays from his blog, Bill Schmalfeldt talks more about the non-motor symptoms of PD - the speech difficulties, the bizarre dreams, the memory problems and the hallucinations - in a way that makes the reader realize that while there's no cure for PD, it can't damage the human spirit (unless you let it) ! Diagnosed with Parkinson's disease in 2000 at the tender age of 45, Bill Schmalfeldt has devoted his life to raising awareness of the disease in America. Click here for more details. For more books concerning Parkinson's Disease go to Parkinson's Disease Books. For Bill Schmalfeldt's blog go to My Parkinson's Diary.
22nd September 2010 - New research
ADVERSE EFFECTS OF DEEP BRAIN STIMULATION
World Neurosurgery  73 (4)
: 338-344 (F.Vergani, A.Landi, D.Pirillo, R.Cilia, A.Antonini, E.P.Sganzerla)
16th September 2010 - New research
GENETIC MUTATIONS IN EARLY PARKINSON'S DISEASE
Archives of Neurology  67
(9) : 1116-1122 (Alcalay RN, Caccappolo E, Mejia-Santana H, Tang MX, Rosado L,
Ross BM, Verbitsky M, Kisselev S, Louis ED, Comella C, Colcher A, Jennings D,
Nance MA, Bressman SB, Scott WK, Tanner C, Mickel S, Andrews H, Waters C, Fahn
S, Cote L, Frucht S, Ford B, Rezak M, Novak K, Friedman JH, Pfeiffer R, Marsh L,
Hiner B, Siderowf A, Ottman R, Marder K, Clark LN.)
12th September 2010 - New research
TRANSCRANIAL MAGNETIC STIMULATION FOR PARKINSON'S DISEASE
Movement Disorders  Aug
24. [Epub ahead of print] (Pal E, Nagy F, Aschermann Z, Balazs E, Kovacs N.)
For full details of the method go to the Oxford Handbook of Transcranial Stimulation. In the clinical trial, depression was improved 30 days after treatment ended. Parkinson's Disease symptoms aimproved during the clinical trial but not by much. In a previous study, TMS reduced some Parkinson's Disease symptoms. The effect appears to have been achieved by increasing dopamine levels. For more information go to the Complete abstract. In order to refer to this article on its own click here.
9th September 2010 - New research
PHYSICAL ACTIVITY AND THE RISK OF PARKINSON'S DISEASE
Neurology  75 (4) : 341-348 (Xu Q, Park Y, Huang X, Hollenbeck A, Blair A, Schatzkin A, Chen H.) Complete abstract
Higher levels of regular
moderate to vigorous activity when somebody is in their late thirties and in the
past ten years has been found to reduce the risk of Parkinson's Disease by 40%.
Moderate to vigorous activities at earlier ages (prior to their late thirties),
or light activity had no effect on the likelihood of developing Parkinson's
The primary symptom of
Parkinson's Disease is excessive muscle contraction. Although the initial effect
to increase muscle contraction, the after effect of exercise is to reduce
reduce muscle contraction. This has the same type of effect on the muscles as
most Parkinson's Disease drugs. However, exercise does not raise dopamine levels
as most Parkinson's Disease drugs do. So exercise does not directly affect
Parkinson's Disease, but can reduce the proneness to it. Consequently, a lack of
physical activity could also increase the proneness to developing Parkinson's
Disease. In order to refer to this article on its own
7th September 2010 - New research
THOUGHT DISORDERS IN PARKINSON'S DISEASE
Journal of Neural Transmission
 Aug 29. [Epub ahead of print] (Debs R, Cochen De Cock V, Nègre-Pagès L,
Aristin M, Senard A, Rascol O.)
3rd September 2010 - New research
EARLY LIFE FACTORS AND PARKINSON'S DISEASE
Movement Disorders  25
(11) : 1560-1567 (Gardener H, Gao X, Chen H, Schwarzschild MA, Spiegelman D,
1st September 2010 - New research
THE GENETIC LIKELIHOOD OF PARKINSON'S DISEASE
Journal of Human Genetics  55 (4) : 241-243 (T.H.Hamza, H.Payami) Complete abstract
Researchers questioned whether the evidence for the genetic likelihood of Parkinson's Disease could be explained by the susceptibility genes that have already been identified. They estimated heritability of risk and age at onset of Parkinson's Disease in a large sample of families. After excluding families with known genetic mutations and accounting for the main genes likely to cause Parkinson's Disease, they found the likelihood of inheriting Parkinson's Disease to be 41%. However, this study did not take account of families passing on their non-genetic factors, such as physical environment, dietary habits, and medicine use.
In order to properly assess the genetic likelihood of developing Parkinson's Disease they would need to assess twins separated at birth. However, even when twins not separated at birth were assessed, it was found that the genetic likelihood of developing Parkinson's Disease was only 10% in twins. For more details go to the Complete abstract. The results suggest that Parkinson's Disease is not inherited except in the rarer cases, where there is a specific genetic mutation. In order to refer to this article on its own click here.