16th September 2010 - New research


Archives of Neurology [2010] 67 (9) : 1116-1122 (Alcalay RN, Caccappolo E, Mejia-Santana H, Tang MX, Rosado L, Ross BM, Verbitsky M, Kisselev S, Louis ED, Comella C, Colcher A, Jennings D, Nance MA, Bressman SB, Scott WK, Tanner C, Mickel S, Andrews H, Waters C, Fahn S, Cote L, Frucht S, Ford B, Rezak M, Novak K, Friedman JH, Pfeiffer R, Marsh L, Hiner B, Siderowf A, Ottman R, Marder K, Clark LN.) Complete abstract

In people with early onset Parkinson's Disease, which was defined as developing Parkinson's Disease at age 50 or earlier, about one in six had genetic mutations known to make Parkinson's Disease more likely. Mutations occurred in 40% of those people who developed Parkinson's Disease by 30 years of age. For those people who developed Parkinson's Disease between 31 and 50 years old the likelihood was about one in seven. This likelihood was far greater in people of Jewish ancestry, as nearly a third of those had genetic mutations known to make Parkinson's Disease more likely. The genetic mutation most responsible for Parkinson's Disease, the Parkin gene, was most common of all in people with Hispanic ancestry. Although genetics are not  a factor at all for most people with Parkinson's Disease, in those people with specific genetic mutations, the likelihood pf developing Parkinson's Disease becomes far greater but not inevitable. F
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