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PARKINSON'S DISEASE NEWS
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SEPTEMBER 2009 30th September 2009 - New book DEEP BRAIN STIMULATION Peter Bain, Tipu Aziz, Xuguang Liu, Dipankar Nandi
September 2009 - New research OCCUPATIONS ASSOCIATED WITH
PARKINSON'S DISEASE
26th September 2009 - New book UNDERSTANDING PARKINSON'S DISEASE : A SELF-HELP GUIDE David L. Cram, Xiao Gao, Steven Schechter
22nd September 2009 - New research THE PREVALENCE OF HALLUCINATIONS
IN PARKINSON'S DISEASE
18th September 2009 - New research SUICIDE IS FIVE TIMES MORE
LIKELY IN PARKINSON'S DISEASE People with Parkinson's Disease have been found to be five times more likely to commit suicide. In some people with Parkinson's Disease, this tendency increases far beyond that. Current thoughts of death or suicide were found in nearly a quarter of people with Parkinson's Disease. This tendency was related to mood, especially depression, rather than the severity of Parkinson's Disease symptoms.
14th September 2009 - New book BENEFICIAL EFFECTS OF PHYSIOTHERAPY ON FUNCTION IN PARKINSON'S DISEASE Muhammed Al - Jarrah
11th September 2009 - News release THE WORLD'S SMALLEST DEEP BRAIN
STIMULATOR FOR PARKINSON'S DISEASE
9th September 2009 - New research THE EFFECT OF ROPINIROLE
(REQUIP) ON PARKINSON'S DISEASE
5th September 2009 - New research RETINAL STEM CELLS DISAPPEAR
AFTER SURGERY FOR PARKINSON'S DISEASE A 68-year-old man underwent surgical implantation of 325,000 RPE cells in Spheramine (gelatin microcarriers) for the treatment of Parkinson's Disease. He happened to die six months after the surgery took place. This enabled the researchers to see what happened to retinal stem cells after surgical implantation. Over 99.9% of the cells had disappeared after only six months. Implanted cells simply failed to survive. A previous study using the same methods demonstrated only a moderate benefit for six months. For more details see the Complete abstract. Despite different forms of stem cell surgery now being carried out in countries around the world, there is not even one study in the entire medical literature showing that anybody has ever been rid of Parkinson's Disease by this means. In order to refer to this article on its own click here.
2nd September 2009 - News report PIMAVANSERIN
FAILS CLINICAL TRIAL FOR PARKINSON'S DISEASE
1st September 2009 - History LEONARDO DA VINCI'S DESCRIPTIONS OF PARKINSON'S DISEASEThe Italian artist, engineer and scientist Leonardo da Vinci (1452-1519) also studied anatomy, physiology and medicine. Leonardo da Vinci kept secret notebooks in which he wrote and sketched his ideas and observations, in handwriting that only he could read. So keen was he to study the human body that he went out at night to dissect human corpses. For more information go to Leonardo da Vinci. Over 300 years before James Parkinson formally described Parkinson's Disease, Leonardo da Vinci saw people whose symptoms coincided with those seen in Parkinson's Disease. Leonardo wrote in his notebooks that "you will see.....those who.....move their trembling parts, such as their heads or hands without permission of the soul; (the) soul with all its forces cannot prevent these parts from trembling." In a translation of Da Vinci's notebooks "The movements of paralytics of those benumbed by cold, whose head and members move without control of the soul, who cannot stop the movements." The combination of difficulty with voluntary movement ("paraletici") and tremor ("tremanti') leave little doubt of the diagnosis of Parkinson's Disease. At the end of his life Leonardo was unable to paint due to the loss of control of movement in his hands. It has been suggested that, by then, Leonardo had the disorder himself. Due to most of his notebooks remaining secret for centuries, Leonardo did not receive any credit for contributing to the recognition of Parkinson's Disease. In order to refer to this article on its own click here.
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Publisher's
description : Deep brain stimulation (DBS) is increasingly used for the
treatment of patients with severe Parkinson's disease, but the technique and
science behind it is still poorly understood by most clinicians. This book is
intended to provide an overview of the use of DBS for movement disorders. The
first part of the book covers the varying surgical techniques involved in
implanting electrodes into various deep nuclei within the brain. The neuro-physiological
techniques involved in this process and the complex issue of programming the
implanted stimulator in order to optimize therapeutic efficacy and minimize
stimulation induced adverse effects. The second part of the book describes how
to select appropriate patients and describes the results of DBS treatment for
Parkinson's disease, dystonia and tremors. Edited by three of the world's
leading experts in the DBS field, this pocketbook provides neurologists,
trainees, and specialist nurses with an overview of the therapeutics use of DBS.
Work
in agriculture, education, health care, or welding was not associated with
increased risk of Parkinsonism. Unexpected increased risks associated with
legal, construction and extraction, or religious occupations were not maintained
after adjustment for duration. However, having worked in business, finance,
legal occupations, construction and extraction, or transportation and material
moving was associated with postural instability and gait difficulty.
None of the occupations,
job tasks, or task-related exposures were associated with Parkinson's Disease
being diagnosed at a younger age. Pesticide use made the likelihood of
Parkinsonism almost twice (1.9 times) more likely. Use of any of 8 pesticides
more than doubled (2.2 times) the likelihood. This risk was even higher (2.59
times more likely) with the use of 2,4-dichlorophenoxyacetic acid.
In order to refer to this article
on its own 
Publisher's
description : A simple, sympathetic guide to coping with a progressive,
disabling brain disorder. Physician Cram was diagnosed with Parkinson's disease
ten years ago. Here he matches his personal experience with his experiences
treating other patients with the disease. Cram is a firm believer in four
elements to self-help : a positive attitude, information about the disease;
partnership with a knowledgeable physician, and a willingness to take action, to
do the things "that make you feel better, help slow the disability, and keep you
as independent as possible for as long as possible.'' Cram goes on to explain
the overall progression of the disease through five stages. The hope he offers
is that early self-help and medication may delay or even prevent the later
stages. He looks at at emotional considerations, diet, exercise, and
other lifestyle needs, as well as present and possible medical
treatments.
Delusions affect only about 5%. Hallucinations persist and
worsen and their prevalence increases with time. The symptoms are usually due to
Parkinson's Disease drugs. Dopaminergic agonists increase the likelihood of
symptoms, but there is no simple dose-effect relationship between dopaminergic
treatments and the presence or severity of hallucinations. Other factors
associated with hallucinations include older age, duration of Parkinson's
Disease, disease severity, altered dream phenomena, and daytime sleepiness. In
order to refer to this article on its own
The primary cause of
Parkinson's Disease is insufficient dopamine. Although insufficient dopamine
causes the excessive muscle contraction that is characteristic of Parkinson's
Disease, insufficient dopamine also affects the emotions, tending to make people
more prone to depression. This is why depression is common in many, but
certainly not all people with Parkinson's Disease. So the increased likelihood
of suicide and suicidal thoughts in Parkinson's Disease is largely caused due to
a biochemical deficiency of dopamine rather than by the practical problems and
circumstances that Parkinson's Disease can lead to.
In order to refer to this article
on its own 
Publisher's
description : Drugs used to treat PD halt the symptoms of the disease for a few
years, but later can result in serious complications. Surgery as another option
available to treat PD has been shown to carry significant risk factors
and treat only certain symptoms of PD. Several studies demonstrated that
exercise provides protection against PD and lowers the risk of getting PD, but
most of these studies did not examine the physiological mechanisms of how
exercise helps patients with PD. In this book, we conducted experiments to begin
to narrow down the possible changes occurring with exercise in
chronic/progressive animal model of PD that would explain the beneficial
outcomes. These mechanisms include the beneficial effect of exercise on
Respiratory parameters such as O2 consumption, CO2 production, and heat production
in cardiac and skeletal muscles.
Over a
quarter
(28%) of people taking Ropinirole reported adverse reactions. The
most frequent adverse reactions were somnolence and sedation (9%),
gastrointestinal symptoms (7%), increase in dyskinesia (6%), and orthostatic
symptoms (4%). Treatment using Ropinirole was withdrawn in 14% of patients,
largely because of either adverse reactions, lack of efficacy, or change in
treatment. Over 80% of people taking Ropinirole were considered by their
neurologists to have improved after taking it.
In order to refer to this article
on its own 
Retinal pigment epithelial cells have been found to disappear after being used
in a form of surgery intended for use in Parkinson's Disease. For years, the use
of implanted stem cells have been claimed to have the potential to rid
Parkinson's Disease. One of these means is the use of RPE
(retinal pigment epithelium) cells. These cells are
found in the eyes and can also produce dopamine, the substance whose deficiency
causes Parkinson's Disease.
Parkinson's Disease
is
largely
due to insufficient dopamine. Psychosis appears to be due to almost the opposite
- an excess or an accumulation of dopamine. This is why anti-psychotic drugs can
cause Parkinson's Disease symptoms, and why Parkinson's Disease drugs can
sometimes cause symptoms of psychosis. Pimavanserin is a "5-HT 2A receptor
inverse agonist". Biochemically that could have no effect on the excessive
dopamine found in psychosis. So the failure of Pimavanserin in clinical
trials is almost predictable.
The psychosis sometimes experienced in Parkinson's
Disease is normally due to the excessive use of dopaminergic drugs. So a
reduction in the use of those drugs is a more rational approach than using an
additional drug to combat the effects of dopaminergic drugs.
In order to refer to this article
on its own 
