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Parkinson's Disease News covers all significant new research, reports, books, and resources concerning Parkinson's Disease. Articles are chosen on the basis of their medical significance or potential interest. Our overwhelming priority is the facts, regardless of whether they contradict prevailing views or vested interests. Analysis and further information are provided either to explain the background or implications, or to balance misleading claims. If you notice errors or inadequacies, or dispute what is written, or want to propose articles, please e-mail [email protected].

                                           

 

18th October 2018 - New research

ONO-2160 - A NEW L-DOPA PRO-DRUG FOR PARKINSON'S DISEASE

 CLICK HERE FOR A PRINTABLE OR WHITE BACKGROUND VERSION OF THIS ARTICLE

ONO-2160 is a new drug being developed for the treatment of Parkinson's Disease. It also includes carbidopa, which is the same as is included in Sinemet. ONO-2160 is an L-dopa pro-drug, which means that once absorbed it is converted into L-dopa.

An open study clinical trial was carried out on people with Parkinson's Disease in which ONO-2160 and carbidopa was compared to the use of L-dopa and carbidopa, which is what is in Sinemet. Patients were primarily evaluated using the Unified Parkinson's Disease Rating Scale Part III, a Parkinson's disease symptom diary, and analysis of adverse events.

Pharmacokinetic analysis of plasma levodopa concentration was also performed. ONO-2160 and carbidopa therapy stabilized the plasma concentration of L-dopa better than L-dopa with carbidopa. No adverse events with safety concerns were observed. The combination of ONO-2160 and carbidopa produced a prolonged and stable plasma L-dopa concentration whilst also reducing the Parkinson's Disease symptom scores. The combination was well tolerated with no safety concerns. The results suggest an improved method of administering L-dopa.

Reference : eNeurologicalScience [2018] 13 : 8-13 (M.Nomoto, M.Nagai, N.Nishikawa, R. Ando, Y. Kagamiishi, K.Yano, S.Saito, A.Takeda)  Complete abstract   For more news go to Parkinson's Disease News

 

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THE COMPREHENSIVE GUIDE TO PARKINSON'S DISEASE

 The Comprehensive Guide to Parkinson's Disease, which is fully referenced, and over 800 pages long, is the most comprehensive book concerning Parkinson's Disease. It includes the history of Parkinson 's Disease, famous people with Parkinson's Disease, the complete biochemisty of Parkinson's Disease, its cytology and cytological effects, anatomy and anatomical effects, physiology and physiological effects, symptoms of every system in the body, the diagnosis methods (observational, technological, chemical), biochemical causes, all the toxic causes, all the genetic causes, all the pharmacological causes, all the medical disorders that cause Parkinson's Disease symptoms, its treatments (biochemical, pharmacological, surgical, natural, exercise methods, technological methods), including all those treatments that exist and all those treatments presently being developed, Parkinson's Disease organisations, Parkinson's Disease web sites, and books on Parkinson's Disease nursing. CLICK HERE FOR MORE DETAILS

 


 

 

 

 

 

 

 

 

 

 

 

 

 

 

 
 
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2018-10-18 21:43:54
 
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