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Parkinson's Disease News covers
all significant new research, reports, books, and resources concerning
Parkinson's Disease.
Articles are chosen on the basis
of their medical significance or potential interest. Our overwhelming priority
is the facts, regardless of whether they contradict prevailing views or vested
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either to explain the background or implications, or to
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6th January 2018 - New research
L-DOPA INHALER RAPIDLY IMPROVES PARKINSON'S DISEASE
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Background : The L-dopa inhaler CVT-301 is presently being assessed for its
use in Parkinson's Disease. It is designed to deliver a precise dose of a
dry powder formulation of L-dopa. Inhaled L-dopa enters the body through the
lungs and then reaches the brain far more quickly by bypassing the digestive
system. For more information go to :
CVT-301
 Methods
: Patients used the L-dopa inhaler CVT-301 up to 3 times per day for OFF
episodes. After 2 weeks, the study-drug dose was increased from 35mg to 50
mg. The patients were assessed after 10, 20, 30, and 60 minutes. Results:
The L-dopa inhaler was used at an average of 2.1 times per day. The UPDRS
Part III score (Parkinson's Disease symptoms) clearly improved. A treatment
effect was already evident after only 10 minutes.
Adverse effects : The most frequently reported
adverse events in those using CVT-301 were dizziness, cough, and nausea,
each in 7% of patients.
Conclusion : As the effect was already seen after 10 minutes, which is
the shortest time assessed, the effect could be even quicker. Consequently,
CVT-301 could become of widespread use in Parkinson's Disease for when a
quick effect is needed.
Reference : Movement Disorders [2016] 31 (9) : 1356-1365 (P.A.LeWitt,
R.A.Hauser, D.G. Grosset, F.Stocchi, M.H.Saint-Hilaire, A.Ellenbogen,
M.Leinonen, N.B.Hampson, T.DeFeo- Fraulini, M.I.Freed, K.D.Kieburtz)
Complete
abstract
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