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Parkinson's Disease News covers
all significant new research, reports, books, and resources concerning
Parkinson's Disease.
Articles are chosen on the basis
of their medical significance or potential interest. Our overwhelming priority
is the facts, regardless of whether they contradict prevailing views or vested
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either to explain the background or implications, or to
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29th May - New research
CLINICAL TRIAL OF SAFINAMIDE FOR PARKINSON'S DISEASE
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Safinamide has both dopaminergic properties (highly selective and reversible
inhibition of monoamine oxidase-B) and non-dopaminergic properties
(selective sodium channel blockade and calcium channel modulation, with
consequent inhibition of excessive glutamate release). It is usually added
to the use of L-dopa or dopamine agonists. For more information go to Xadago
:
Xadago
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The use of L-dopa is limited by wearing off and dyskinesias. The
objective of this study was to investigate the efficacy and safety
of safinamide in L-dopa treated patients who had motor fluctuations.
If no tolerability issues arose by day 14, the starting dose, 50 mg,
was increased to 100 mg. When taking safinamide, the mean change in
daily on time without dyskinesia 2.80 hours. However, this was not
much different from the effect that a placebo had. The most
frequently reported adverse event was dyskinesia (14%], and as a
severe event (2%). These results are consistent with previous
studies in which the increase in "on" time beyond that of a placebo
was only 40 minutes for 50mg safinamide, and 50 minutes for 100mg
safinamide.
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Parkinson's Disease News
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Reference : JAMA Neurology [2017] 74 (2) :
216-224 (A.H.Schapira, S.H.Fox, R.A.Hauser, J.Jankovic, W.H.Jost, C.Kenney,
J.Kulisevsky, R.Pahwa, W.Poewe, R.Anand)
Complete abstract
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