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21st March 2017 - New research
LOSS OF L-DOPA EFFECT IN ADVANCED PARKINSON'S DISEASE
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Late-stage Parkinson's Disease is dominated by
the loss of autonomy due to motor and non-motor symptoms which can be
marginally corrected by medication adjustments. However, controversy exists
on the mechanisms underlying the decrease in benefit from L-dopa. So
researchers assessed the response to L-dopa in late-stage Parkinson's
Disease.
People
with late stage Parkinson's Disease and people who had undergone Deep Brain
Stimulation underwent an acute L-dopa challenge test. Those people with late
stage Parkinson's Disease improved by only 11%, whereas those people who had
undergone Deep Brain Stimulation improved by 37%. Rest tremor showed the
largest improvement. However, the magnitude of the response to L-dopa was
significantly correlated with the severity of dyskinesias in people with
late stage Parkinson's Disease.
As the Parkinson's Disease symptoms improved, even though the improvement
was mild, the dyskinesia worsened. A decrease in L-dopa response is
therefore an indicator of the progression of Parkinson's Disease.
Reference : Parkinsonism and Related Disorders
[2016] 26 : 10-16 (M.Fabbri, M.Coelho, D.Abreu, L.C.Guedes, M.M.Rosa,
N.Costa, A.Antonini, J.J.Ferreira)
Complete abstract
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