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Parkinson's Disease News covers all significant new research, reports, books, and resources concerning Parkinson's Disease. Articles are chosen on the basis of their medical significance or potential interest. Our overwhelming priority is the facts, regardless of whether they contradict prevailing views or vested interests. Analysis and further information are provided either to explain the background or implications, or to balance misleading claims. If you notice errors or inadequacies, or dispute what is written, or want to propose articles, please e-mail [email protected].

                                          

 

5th March 2014 - New research

L-DOPA'S EFFECT ON NON-MOTOR SYMPTOMS OF PARKINSON'S DISEASE

Mymensingh Medical Journal [2014] 23 (1) : 18-23 (M.M.Rahman, M.J.Uddin, J.H. Chowdhury, T.I.Chowdhury) Complete abstract

People with Parkinson's Disease have the characteristic motor symptoms of Parkinson's Disease but also have a wide range of non-motor symptoms. Although L-dopa is a widely used basis for treating Parkinson's Disease, L-dopa (with carbidopa) has been found to have little effect on many of the non-motor symptoms of Parkinson's Disease.

When assessed, the most frequent non-motor symptoms of Parkinson's Disease were fatigue 56%, excessive sweating 54%, insomnia 54%, akathisia (restlessness) 47%, anxiety 45%, and constipation 17%. However, after five months of taking L-dopa and carbidopa, frequencies of most of the non-motor symptoms decreased only slightly, showing that there was little significant effect of L-dopa and carbidopa.

Some non-motor symptoms of Parkinson's Disease are not improved by taking L-dopa because they are due to the side effects of Parkinson's Disease drugs. Some non-motor symptoms of Parkinson's Disease are not improved much by taking L-dopa because they are due to a combination of Parkinson's Disease and other factors that are not related to the dopamine deficiency that occurs in Parkinson's Disease. For more news go to Parkinson's Disease News.

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