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Parkinson's Disease News covers all significant new research, reports, books, and resources concerning Parkinson's Disease. Articles are chosen on the basis of their medical significance or potential interest. Our overwhelming priority is the facts, regardless of whether they contradict prevailing views or vested interests. Analysis and further information are provided either to explain the background or implications, or to balance misleading claims. If you notice errors or inadequacies, or dispute what is written, or want to propose articles, please e-mail [email protected].

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17th November 2013 - New research

FUNGAL CAUSE OF PARKINSON'S DISEASE

Proceedings of the National Academy of Sciences USA [2013] Nov 11 [Epub ahead of print] (A.A.Inamdar, M.M.Hossain, A.I.Bernstein, G.W.Miller, J.R.Richardson, J.W.Bennett) Complete abstract

Octenol (1-octen-3-ol), which is commonly known as mushroom alcohol, is produced by several plants and fungi. For more information go to Octenol. In Drosophila melanogaster (the common fruit fly) Octenol reduces the levels of dopamine, the substance whose deficiency causes Parkinson's Disease.

Although it has not yet conclusively been proven to have caused Parkinson's Disease in humans, further experiments in human cells revealed that Octenol interfered with two genes involved in the creation of dopamine - the human plasma membrane dopamine transporter (DAT) and the human VMAT ortholog (VMAT2). This demonstrates that 1-octen-3-ol exerts toxicity via disruption of dopamine homeostasis and so may represent a naturally occurring cause of Parkinsonism. Octenol can often be inhaled by humans after being produced in damp, mouldy or water damaged buildings. For more news go to Parkinson's Disease News.

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