9th September 2012 - New research


Parkinsonism Related Disorders [2012] Sep 3 [Epub ahead of print] (Oertel W, Lewitt P, Giladi N, Ghys L, Grieger F, Boroojerdi B.) Complete abstract

Although dopamine agonists are sometimes perceived as poorly tolerated by the elderly, there is little clinical evidence to support these concerns. So the safety and tolerability of rotigotine transdermal system have been assessed in four 6-month studies. : two in early Parkinson's Disease and two in advanced Parkinson's Disease. Neupro® (Rotigotine Transdermal System) is a dopamine agonist that is applied to the skin in order to continuously deliver rotigotine over a 24-hour period. For more information go to Neupro.

For most adverse events no age-related differences in were observed. In early Parkinson's Disease those symptoms more common in those younger than 65 in comparison to those who were 65 were : nausea (38% v 30%) and headache (15% v 9%). In another study, amongst older patients, those symptoms more common in those younger than 75 in comparison to those who were 75 were : nausea (36% v 21%), and dizziness (15% v 28%). In people with advanced Parkinson's Disease it was still the younger patients that more commonly had nausea (24% v 19%). It was only falls that were more common in older patients (13% v 8%). So oddly, the adverse events of this dopamine agonists were generally less rather than greater with age, as if the adverse events were adapted to. For a printable version of this article click hereFor more news go to Parkinson's Disease News.


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Parkinson's Disease News details all significant new research, news reports, new books, and new resources concerning Parkinson's Disease and those medical disorders that often coincide with Parkinson's Disease. It is compiled from an analysis of  all newly published research, news reports, new clinical trials, all newly published books, and new web sites. A summary and analysis of the new research are provided,  as well as links to the complete abstracts and news reports



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2015-09-01 12:19:58
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