In people with early Parkinson's Disease taking a dopamine agonist, the effect of 200mg safinamide was found to be little different from that of a placebo. The effect of 100mg safinamide was found to be significantly better than a placebo. In previous clinical trials, after six months, once daily dosages of 50mg to 100mg Safinamide improved Parkinson's Disease symptoms, and reduced "off" time when added on to the use of existing Parkinson's Disease treatments. However, the reduction in "off" time in comparison to the use of a placebo was minimal. The increase in "on" time beyond that of a placebo was only 40 minutes for 50mg safinamide, and 50 minutes for 100mg safinamide. The side effects of the clinical studies were not disclosed. Higher dosages did not have any beneficial effect. For more current news go to Parkinson's Disease News.

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