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16th July 2011 - New research

DUAL LAYER L-DOPA CLINICAL TRIAL RESULTS

Movement Disorders [2011] Jul 13 [Epub ahead of print] (R.A.Hauser, A.L.Ellenbogen, L.V.Metman, A.Hsu, M.J. O'Connell, N.B.Modi, H.M.Yao, S.H.Kell, S.K.Gupta) Complete abstract

L-dopa combined with carbidopa usually comes in two different forms : either the immediate release version (such as Regular Sinemet), which satisfies the immediate need for L-dopa, or the controlled release version (such as Sinemet CR), which avoids the excessive effects of L-dopa by spreading out the effects of the L-dopa over time.

Dual layer L-dopa combines the two types of L-dopa and carbidopa - an immediate release form and a controlled release form, all in the same tablet. Dual layer L-dopa is consequently being developed as a possible replacement for Sinemet and Sinemet CR. Dual layer L-dopa (IPX054) was shown to be slightly more effective than conventional forms of L-dopa, despite having to be taken only twice a day instead of throughout the day. For more details go to the Complete abstract.  Dual layer L-dopa (IPX066) increased L-dopa levels at the same rate as immediate release L-dopa and carbidopa, and also provided more sustained L-dopa concentrations. It also substantially reduced the variability in plasma concentrations of L-dopa, despite being taken less often. For more current news go to Parkinson's Disease News.

 

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Parkinson's Disease News details all significant new research, news reports, new books, and new resources concerning Parkinson's Disease and those medical disorders that often coincide with Parkinson's Disease. It is compiled from an analysis of  all newly published research, news reports, new clinical trials, all newly published books, and new web sites. A summary and analysis of the new research are provided,  as well as links to the complete abstracts and news reports

                                    

 

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