PARKINSON'S DISEASE NEWS

5th May 2011 - New research

PARDOPRUNOX - A NEW DOPAMINE AGONIST FOR PARKINSON'S DISEASE

Movement Disorders [2011] May 3 [Epub ahead of print] (C.Sampaio, J.Bronzova, R.A.Hauser, A.E.Lang, O. Rascol, S.V.van de Witte, A.A.Theeuwes) Complete abstract

This study presents the results of two clinical trials concerning the efficacy and safety of Pardoprunox in people with early Parkinson's disease. Pardoprunox is a partial dopamine agonist that is presently being assessed. It unusually combines two effects as if it were two distinct but combined drugs : partially stimulating dopamine, whose deficiency causes Parkinson's Disease, and fully stimulating serotonin. It was thought that Pardoprunox could avoid some of the severe side effects dopamine agonists cause by lessening the effect of dopamine when dopamine activity is high.

Pardoprunox showed a significant benefit in reducing Parkinson's Disease symptoms. In one study 6mg was better than 12mg or 12mg-42mg. However, in another study, Pardoprunox was not quite as effective as the dopamine agonist pramipexole (Mirapex). Pardoprunox tolerability was dose related. The higher dosages showed the highest drop out rate due to adverse events, which occurred in about half of patients. The main problems caused were nausea, somnolence, and dizziness. Observations suggest that the 12mg-42mg per day dose range was higher than therapeutically required. For more current news go to Parkinson's Disease News.

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Parkinson's Disease News details all significant new research, news reports, new books, and new resources concerning Parkinson's Disease and those medical disorders that often coincide with Parkinson's Disease. It is compiled from an analysis of  all newly published research, news reports, new clinical trials, all newly published books, and new web sites. A summary and analysis of the new research are provided,  as well as links to the complete abstracts and news reports