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31st July 2010 - New research

MIRAPEX ER CLINICAL TRIAL RESULTS

Movement Disorders [2010] Jul 28 [Epub ahead of print] (Hauser RA, Schapira AH, Rascol O, Barone P, Mizuno Y, Salin L, Haaksma M, Juhel N, Poewe W.) Complete abstract

Movement Disorders [2010] Jul 28 [Epub ahead of print] (Rascol O, Barone P, Hauser RA, Mizuno Y, Poewe W, Schapira AH, Salin L, Sohr M, Debieuvre C) Complete abstract

The objective of this study was to evaluate the efficacy and safety of pramipexole extended release (ER) administered once daily in early Parkinson's Disease. Pramipexole extended release (ER) is marketed as Mirapex ER. Pramipexole immediate release (IR) is administered three times daily. Pramipexole ER was proven to be effective. The level of efficacy was almost identical to that of immediate release Pramipexole, demonstrating that there was no loss of activity when changing over from the immediate release version of Pramipexole. Adverse events more common with Pramipexole ER than placebo included somnolence, nausea, constipation, and fatigue.

In a separate study, the feasibility was assessed, in early Parkinson's Disease, of an overnight switch from immediate-release (IR) pramipexole to a once-daily extended-release (ER) pramipexole. Over 80% of people successfully changed over to the extended release version of pramipexole after 4 weeks, and around 85% successfully changed over to the extended release version of pramipexole after 9 weeks. So changing over to the extended release version is not quick and always successful. For more current news go to Parkinson's Disease News.

 

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Parkinson's Disease News details all significant new research, news reports, new books, and new resources concerning Parkinson's Disease and those medical disorders that often coincide with Parkinson's Disease. It is compiled from an analysis of  all newly published research, news reports, new clinical trials, all newly published books, and new web sites. A summary and analysis of the new research are provided,  as well as links to the complete abstracts and news reports

                                    

 

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