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9th July 2010 - New research

GENE THERAPY FOR PARKINSON'S DISEASE

Molecular Therapy [2010] Jul 6 [Epub ahead of print] (Muramatsu SI, Fujimoto KI, Kato S, Mizukami H, Asari S, Ikeguchi K, Kawakami T, Urabe M, Kume A, Sato T, Watanabe E, Ozawa K, Nakano I.) Complete abstract

The primary fault in Parkinson's Disease is the inability to produce sufficient dopamine via dopamine producing enzymes in the brain. Gene transfer of dopamine producing enzymes into the brain has led to recovery in animal
models of Parkinson's Disease. So researchers evaluated the safety, tolerability, and potential efficacy of adeno-associated virus (AAV) gene delivery of the enzyme that produces dopamine into the brain of people with Parkinson's Disease. Six Parkinson's Disease patients were evaluated at the start and after six months, using a variety of measures. The procedure was well tolerated. Six months after surgery, motor functions in the off-medication state improved by an average of 46% based on the UPDRS symptom questionnaire. Assessment using scanning saw a 56% improvement, which persisted up to 96 weeks.
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Parkinson's Disease News details all significant new research, news reports, new books, and new resources concerning Parkinson's Disease and those medical disorders that often coincide with Parkinson's Disease. It is compiled from an analysis of  all newly published research, news reports, new clinical trials, all newly published books, and new web sites. A summary and analysis of the new research are provided,  as well as links to the complete abstracts and news reports

                                    

 

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