27th February 2010 - New research


Drug Safety [2010] 33 (2) : 147-161 (Kulisevsky J, Pagonabarraga J.) Complete abstract
                                                                                                                                                                                 The tolerability and safety of ropinirole (Requip) in the treatment of Parkinson's Disease, was compared to those of other dopamine agonists  (bromocriptine, cabergoline, pramipexole, rotigotine, pergolide), the use of a placebo, and when used alongside L-dopa. Thirty three years worth of clinical trials were assessed. In all the studies included, dopamine agonists, including ropinirole (Requip), exhibited a higher likelihood of adverse events than the use of a placebo. The occurrence of constipation when using ropinirole (Requip) was only 55% of that of bromocriptine (Parlodel), and 25% of that of L-dopa. There was no difference between ropinirole (Requip) and rotigotine (Neupro) regarding constipation and dyskinesia. For nausea, pergolide (Permax) was worse than ropinirole (Requip), but only narrowly. Both were worse than rotigotine (Neupro). All were clearly worse than the use of a placebo. Ropinirole (Requip) was worse than pramipexole (Mirapex) regarding  nausea, dizziness, sleepiness and dyskinesia. Worst for hallucinations was pergolide (Permax) then rotigotine (Neupro), then pramipexole (Mirapex), and finally ropinirole (Requip). Hallucinations were far more likely than when taking a placebo. Confusion and constipation were far worse with pramipexole (Mirapex) compared with placebo. F
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