19th January 2010 - New research


Annals of  Neurology [2009] 66 (6) : 792-798 (Elstner M, Morris CM, Heim K, Lichtner P, Bender A, Mehta D, Schulte C, Sharma M, Hudson G, Goldwurm S, Giovanetti A, Zeviani M, Burn DJ, McKeith IG, Perry RH, Jaros E, Krüger R, Wichmann HE, Schreiber S, Campbell H, Wilson JF, Wright AF, Dunlop M, Pistis G, Toniolo D, Chinnery PF, Gasser T, Klopstock T, Meitinger T, Prokisch H, Turnbull DM.) Complete abstract

An increased risk of Parkinson's Disease has been found for the gene for Pyridoxal kinase. Pyridoxal kinase is an enzyme. Enzymes  are chemicals naturally produced by the body that turn one substance in to another in the body. Pyridoxal kinase  ultimately turns the Vitamin B6 (pyridoxine) via pyridoxal in to pyridoxal phosphate. This is why people need to consume vitamin B6 (pyridoxine) in order to produce pyridoxal phosphate.

Pyridoxal phosphate (and therefore pyridoxine) is very important for Parkinson's Disease because it is essential for making use of L-dopa. So without pyridoxine and pyridoxal phosphate, L-dopa is virtually useless. L-dopa simply could not form dopamine. It is therefore not surprising that a disturbance in the gene that makes pyridoxal phosphate can make somebody more likely to develop Parkinson's Disease. Pyridoxine was actually one of the first means of treating Parkinson's Disease. In the 1940's pyridoxine was independently being used in the U.S.S.R. and in the U.S.A.. However, large quantities of pyridoxine (30mg or more) can have a detrimental effect, because it breaks down L-dopa in drug form before it is used. For more current news go to Parkinson's Disease News.


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Parkinson's Disease News details all significant new research, news reports, new books, and new resources concerning Parkinson's Disease and those medical disorders that often coincide with Parkinson's Disease. It is compiled from an analysis of  all newly published research, news reports, new clinical trials, all newly published books, and new web sites. A summary and analysis of the new research are provided,  as well as links to the complete abstracts and news reports.





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