11th August 2009 - New research
THE MICHAEL J.FOX FOUNDATION
FUNDS NINE NEW APPROACHES
The
Michael J. Fox Foundation for Parkinson's Research is funding nine new research
projects for Parkinson's Disease. All of the nearly four million dollar funding
has gone to nine biotech and pharmaceutical
companies. For more
information read the
Press release. The research projects consist of seven "neuroprotective approaches", and two
projects concerning the treatment of dyskinesia. The following provides links to
the details of each of the nine projects
:
* |
The pharmacodynamics
of ReS9-S7, which concerns early stage research in possible toxicity
[1].
The element being researched, alpha-synuclein, has never been shown to cause
Parkinson's Disease, but instead has been found only to be affected as a result of it. |
* |
Exploring curcumin
(which is found in a curry spice) as a possible treatment of
Parkinson's Disease
[2]. Curcumin
is already widely used, due to its ready
availability, but has never rid Parkinson's Disease.
|
* |
The effect of novel
neuronal nicotinic receptor compounds on dyskinesia
[3].
Smoking has the same effect on the nicotinic receptors due its nicotine
contact, yet does not rid dyskinesia. |
* |
Assessment of the
therapeutic efficacy of progranulin in a sub-chronic animal model of
Parkinson’s disease
[4]. Other researchers have already shown
that progranulin has no potential in the treatment of Parkinson's
Disease. |
* |
Validation of LRRK2 as
a drug target for treatment of Parkinson’s disease using antisense
technology
[5]. LRRK2 concerns only a genetic form of
Parkinson's Disease.
|
* |
Optimising lead series
of small molecule inhibitors of LRRK2 to deliver tool compounds and clinical
development candidates
[6]. LRRK2 concerns only a genetic form of
Parkinson's Disease.
|
* |
A novel approach to
characterize the distribution of a potentially therapeutic dominant-negative
inhibitor of TNF in pre-clinical models of PD, and predict the scalability
for an effective delivery of therapy in the human brain
[7]. This aims for drugs to be able to by
pass the blood brain barrier. However, Parkinson's Disease has never
been shown to be due to a deficiency of the blood brain barrier.
|
* |
Pre-clinical
development of a Parkinson’s disease therapy using a glucagon-like peptide
(GLP-1) receptor agonist
[8]. It is already approved by the FDA, but
for diabetes rather than Parkinson's Disease.
|
* |
Optimization of MOR antagonists for the treatment of L-DOPA-induced
dyskinesias in Parkinson’s Disease
[9]. The theory behind its use does not,
even in theory, address the fact that dyskinesia is due to excessive L-dopa. |
For more current news go to
Parkinson's Disease News. |
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Parkinson's Disease News details
all significant new research, news reports, new books, and new resources
concerning Parkinson's Disease and those medical disorders that often coincide
with Parkinson's Disease. It is compiled from an analysis of all newly
published research, news reports, new clinical trials, all newly published
books, and new web sites. A summary and analysis of the new research are
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