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19th June 2009 - New research

LEWY BODIES FAIL TO INDICATE PARKINSON'S DISEASE

Journal of neuropathology and experimental neurology [2009] Jun 16. [Epub ahead of print] (Markesbery WR, Jicha GA, Liu H, Schmitt FA.) Complete abstract 

Lewy bodies are often claimed to be the hallmark of Parkinson's Disease. Lewy bodies are basically rubbish bins in the nerve cells, that accumulate debris caused by cell damage. For more information and links go to Lewy Bodies. It is claimed that Lewy Bodies can cause Parkinson's Disease by interfering with the formation of dopamine, and also cause dementia by interfering with the formation of acetylcholine. So researchers assessed the prevalence of Lewy Bodies in people that did not have Parkinson's Disease or dementia, by carrying out autopsies. None of the people assessed had Parkinson's Disease. However, nearly a quarter of the brains were found to include Lewy Bodies in various regions of the brain. This finding contradicts the assertion that Lewy Bodies cause Parkinson's Disease,
because so many people have Lewy Bodies without having Parkinson's Disease.

It has also been previously found that there are many people with Parkinson's Disease that do not have Lewy Bodies either. The researchers still claimed Lewy Bodies "most likely represents preclinical or pre-symptomatic Parkinson disease, Parkinson disease with dementia, or dementia with Lewy bodies." However, their own findings contradict their own suggestion. Rather than Lewy Bodies cause Parkinson's Disease, the results show that Parkinson's Disease, and other medical disorders can sometimes cause Lewy Bodies. For more current news go to Parkinson's Disease News.

 

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Parkinson's Disease News details all significant new research, news reports, new books, and new resources concerning Parkinson's Disease and those medical disorders that often coincide with Parkinson's Disease. It is compiled from an analysis of  all newly published research, news reports, new clinical trials, all newly published books, and new web sites. A summary and analysis of the new research are provided,  as well as links to the complete abstracts and news reports.

                                    

 

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