13th May 2009 - New research
THE PREVALENCE OF
ANXIETY IN PARKINSON'S DISEASE
Movement Disorders [2009] May 7 [Epub ahead of print] (Pontone GM, Williams JR,
Anderson KE, Chase G, Goldstein SA, Grill S, Hirsch ES, Lehmann S, Little JT,
Margolis RL, Rabins PV, Weiss HD, Marsh L.)
Complete abstract
Anxiety disorders are common in Parkinson's Disease, but are not well
characterized. So this study determined the prevalence of anxiety disorders in
Parkinson's Disease. Around 43% of people with Parkinson's Disease were found to
currently have an anxiety disorder. Almost half of people with Parkinson's
Disease were found to have had an anxiety
disorder at some time. Panic disorders were more associated with an earlier age
of onset of Parkinson's
Disease,
and were more common in those people with greater motor fluctuations and
morning dystonia.
This high prevalence of
anxiety disorders suggested to the researchers that anxiety in Parkinson's
Disease is both underdiagnosed and undertreated. The main biochemical fault in
Parkinson's Disease is insufficient dopamine. Low dopamine does not cause
anxiety itself. So anxiety is not an inevitable part of Parkinson's Disease.
L-dopa can end up as noradrenaline, which causes anxiety. So the
high prevalence of anxiety in Parkinson's Disease may be largely due
to the side effects of certain Parkinson's Disease drugs.
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