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PARKINSON'S DISEASE NEWS
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AUGUST 2008
29th August 2008 - News report MOTOR RACING WORLD CHAMPION DIES WITH PARKINSON'S DISEASE Formula 1 Motor racing World champion, Phil Hill has died of the complications of Parkinson's Disease. He is the only American born motor racing driver to have become Formula 1 World Champion. He competed in Formula 1 from 1958 until 1966. The year he became World champion he won the Italian Grand Prix and the Belgian Grand prix, driving a Ferrari.
27th August 2008 - News release AZILECT CLAIMED TO SLOW PROGRESSION OF PARKINSON'S DISEASE Azilect (rasagiline) is a MAO inhibitor that is sometimes used in the treatment of Parkinson's Disease. For more information go to Rasagiline. Teva Pharmaceutical Industries have announced results of the phase III ADAGIO trial concerning Azilect. Teva have claimed that Parkinson's disease patients who took Azilect (rasagiline) 1mg tablets once-daily upon entry into the trial, demonstrated a significant improvement compared to those who initiated the drug 9 months later, implying that it is better to begin the use of Azilect earlier. Consequently, it has been widely claimed that Azilect slows the progression of Parkinson's Disease. However, the claims are misleading and unsubstantiated. As the use of Azilect progressed, those patients that had begun Azilect earlier were no different than those that had started Azilect later.
26th August 2008 - New book PARKINSON'S DISEASE : PATHOGENIC AND THERAPEUTIC INSIGHTS Richard Nass (editor), Serge Przedborski (editor)
24th August 2008 - New research
THE MYTH OF
ALPHA-SYNUCLEIN IN PARKINSON'S DISEASE
18th August 2008 - News report california funds numerous stem cell projects California's stem cell agency has awarded $59 million to support the budgets of 23 researchers to carry out new stem cell research projects. Human stem cells, particularly those found in embryos, are primitive cell types that can be made to differentiate into virtually all the specialized cells and tissues of the body. The California Institute for Regenerative Medicine was created with a $3 billion bond issue in 2004, which had been approved by voters. The Institute has so far awarded more than $614 million. They are consequently the world's biggest funders of stem cell research. It is claimed that stem cell research may be invaluable for various medical disorders including Parkinson's Disease. For more information go to the Complete article.
17th August 2008 - New research
yeast
reduces cell damage in parkinson's disease Alpha-Synuclein can appear in the cells involved in Parkinson's Disease (the dopaminergic neurons). For more information, go to Alpha-Synuclein.
Hsp140, even in theory, does nothing to directly increase dopamine formation, whose deficiency is the primary fault in Parkinson's Disease. Hsp140 is a protein (which is a long chain of amino acids). Consequently it could not be used in Parkinson's Disease anyway, because proteins are too big to pass the blood brain barrier (the barrier between the brain and the blood that prevents large or toxic substances from entering).
15th August 2008 - New book TAKE ME HOME : PARKINSON'S, MY FATHER, MYSELF Jonathan Taylor
13th August 2008 - New research
NSAIDS
increase parkinson's disease
10th August 2008 - New review carbon disulfide as a cause of parkinson's disease
Further references : [8] Journal of neuropathology and experimental neurology [1945] 4 : 324 (R.Richter), [9] British journal of industrial medicine [1954] 11 : 235 (E.C.Vigliani).
8th August 2008 - News research parkinson's disease stem cell line created Cell [2008] (In-Hyun Park, Natasha Arora, Hongguang Huo, Nimet Maherali, Tim Ahfeldt, Akiko Shimamura, M.William Lensch, Chad Cowan, Konrad Hochedlinger, George Q.Daley) Complete study A new collection of disease-specific stem cell lines have been produced, all of which were developed using the new induced pluripotent stem cell (iPS) technique. The new cell lines were developed from the cells of patients suffering from a range of conditions from Down Syndrome to Parkinson's disease. The cell lines the researchers produced carry the genes or genetic components for 10 different diseases, including Parkinson's Disease. They wanted to produce a large number of disease models for stem cell research community to accelerate research.
The biochemistry of the dopaminergic neurons (the cells involved in Parkinson's Disease) is already well known. Therefore, there is limited potential benefit from further examination of these cells. Most medical researchers are not aware of what is already known of the biochemistry of Parkinson's Disease. Consequently, the vast majority of research being carried out in Parkinson's Disease is fundamentally flawed because of false assumptions concerning even the basic biochemistry.
4th August 2008 - News report a ten year old with parkinson's disease At the age of ten, Andrew Carnegie who is now 12 years old, started developing Parkinson's Disease symptoms. He suffered from stiffness and cramps in the muscles. He lost his balance easily, and fell frequently. Numerous attempts at obtaining a diagnosis failed. He was not readily diagnosed with Parkinson's Disease because he was so much younger than the false and stereotypical view of Parkinson's Disease only occurring in old people. After he was eventually diagnosed, regular Sinemet readily rid his symptoms. For more information go to the Complete article.
3rd August 2008 - New forum the irish parkinson's disease forum
2nd August 2008 - New research an autoimmune hypothesis of parkinson's disease Cell Transplantation [2008] 17 (4) : 363-372 (Monahan AJ, Warren M, Carvey PM.) Complete abstract Studies have demonstrated that a number of substances readily cause toxic damage to the cells that produce dopamine. However, neuroprotective strategies aimed at dealing with this toxicity have been largely ineffective in treating Parkinson's Disease. The researchers suggest that this may be because the progression of Parkinson's Disease is a consequence of an additional mechanism. Whilst they considered this, they discovered that animals whose dopamine producing cells were exposed to the neurotoxins exhibited blood-brain barrier (BBB) dysfunction.
In support of their theory, the leading researcher concerning the blood brain barrier in Parkinson's Disease claimed several years ago that the blood brain barrier was dysfunctional in Parkinson's Disease [1] [2]. However, these studies were not age controlled, which is a considerable failing, because people with Parkinson's Disease tend to be older. His subsequent studies effectively nullified the basis for the blood brain barrier theory being dysfunctional in Parkinson's Disease. He first found that the blood brain barrier tended towards being dysfunctional in older people anyway, regardless of whether or not they had Parkinson's Disease [3]. He also found that when people developed Parkinson's Disease they did not have a dysfunctional blood brain barrier [4]. The blood brain barrier being no more dysfunctional in Parkinson's Disease than in anyone else of a similar age leaves the autoimmune theory of Parkinson's Disease without the basis it requires.
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He beat four World champions : Graham Hill, John
Surtees, Jack Brabham, Jim Clark, who between them won the World
championship 8 times. Phil Hill also won the prestigious Le Mans 24 hour
race 3 times.
For more information go to
During weeks 48-72, the effect of earlier use of
Azilect was described as being merely "non-inferior" to those that started
Azilect later.
For more information go to the
Publisher's
description : Despite its high prevalence in society and many decades of
research, the origin of the pathogenesis and the molecular determinants involved
in the disorder has remained elusive. Confounding this issue is the lack of
experimental models that completely recapitulate the disease state. The
identification of a number of genes thought to play a role in the cell death,
and development of both toxin and genetic models to explore the function of the
genes both in unaffected and diseased cells are now providing new insights into
the molecular basis of the neurodegeneration, as well as therapeutic approaches.
In this book, the advances and the advantages that various invertebrates, cell
culture, rodents, and mammals provide in the identification of the molecular
components and mechanisms involved in the cell death will be described, as well
as the opportunities that these systems provide in drug discovery.
In autopsy
studies, 30% to 55% of elderly subjects
with widespread alpha-synuclein pathology were found to have no definite
neuropsychiatric symptoms or were not classifiable. When alpha-synuclein had
accumulated further, Parkinson's Disease was often found to be less.
Alpha-synuclein can also accumulate in Dementia with Lewy Body Disease,
showing that it can appear in other neurological disorders, whilst
not causing Parkinson's Disease at all. Consequently, much of the research presently being carried out concerning Parkinson's Disease is being
done without having any scientific or factual basis.
Although Parkinson's Disease is often claimed to be one of the major
concerns of stem cell
research, virtually none of the projects actually deal specifically with
Parkinson's Disease, as can be seen by the list of
It has been debated as to whether this is to protect the
cells from damage, or
causes
cell damage. Researchers used Hsp104, which is found in yeast, to reduce the
formation of alpha-synuclein, and to prevent cell damage caused by
alpha-synuclein. Hsp140 works with Hsp70 and Hsp40, which are also found in
yeast. It is claimed that Hsp140 protects the cells against the effects of
alpha-synuclein by preventing the accumulation of alpha-synuclein. Researchers
consequently claim that Hsp140 could be used therapeutically in Parkinson's
Disease to prevent the cell damage that often accompanies Parkinson's Disease.
When
Jonathan Taylor was eight, he began to find his father puzzling. The first
thing that happened was that his father couldn't remember Jonathan's
sister's name. Then he began to shake, to drive badly, to forget who or
where he was, and to mistake his son for someone else entirely. "Help help
help," his father would say, on and on, but there seemed to be no helping
him. Doctors diagnosed Parkinson's disease and an associated form of
dementia, and Jonathan gradually became one of his father's carers, taking
it in turn with his family to look after him for the next thirteen years.
Take Me Home is the story of a son's struggle for recognition from a
father who is being transformed mentally and physically by a ruinous
disease, and a writer's struggle to discover a father's strange and
largely secret past - who he was before he became a disappointed
headmaster and, at the last, a trembling Parkinsonian
who sometimes mistook his son for Humphrey Bogart or a giraffe.
Recent studies have found NSAIDs to be protective against the development of
Parkinson's Disease. However, researchers decided to test this hypothesis using
the Saskatchewan drug plan database. Cases were defined as those having received
three prescriptions for a dopamine agonist within a year. Controls were matched
for age, calendar time and index date. Past users of NSAIDs had a slightly
higher risk of developing Parkinson's Disease, increasing their chances by up to
20%. However, the occurrence of Parkinson's Disease was up to 50% higher amongst
those people that were currently using NSAIDs. The researchers have given no
biochemical explanation as to why this might occur. 
Carbon disulfide, usually in solvents or pesticides, can cause Parkinson's
Disease that is associated with other neurological symptoms. The effects can
persist for years after exposure to the carbon disulfide has ceased. 
They believe that these cells are invaluable tools that will allow
researchers to watch the development diseases outside of the patients, and that
this will make it possible to find new treatments, and eventually drugs, to slow
or even stop the course of a number of diseases, including Parkinson's Disease.
"The cell lines available from the iPS Core will allow stem cell researchers
around the world to explore possible gene therapies for some conditions, and
will aid in the development of drugs for others," Daley said.
There
have previously
been children even younger than 10 years old who have had Parkinson's
Disease. The youngest known case of Parkinson's Disease was described in 1875 by
Henri Huchard who had a patient that had all of the symptoms of
Parkinson's Disease who was only three years old. A ten year old American girl
experienced her first symptom at only two
years old. It is uncommon for people under the age of thirty to develop
Parkinson's Disease, which usually occurs when people are significantly older.
However, Parkinson's Disease does not become progressively more likely with age,
because amongst the very oldest of people (those between 110 and 119 years old)
Parkinson's Disease is hardly known.
The
Irish Parkinson's Disease Forum has been set up for Irish people with an
interest in Parkinson's Disease to
discuss Parkinson's Disease, and the issues and events in Ireland concerning it.
This includes the work and activities of the two Irish Parkinson's Disease
organisations : The Parkinson's Association of Ireland, and PALS support group,
which is primarily for younger people. The Irish Parkinson's Disease Forum is at
present the only Parkinson's Disease Forum for Irish people. The forum is independent and open to anyone to become a member. For their web site,
double click on
The