PARKINSON'S DISEASE NEWS
Parkinson's Disease News covers all significant new research, reports, books, and resources concerning Parkinson's Disease. Articles are chosen on the basis of their medical significance or potential interest. Our overwhelming priority is the facts, regardless of whether they contradict prevailing views or vested interests. Analysis and further information are provided either to explain the background or implications, or to balance misleading claims. If you notice errors or inadequacies, or dispute what is written, or want to propose articles, please e-mail email@example.com.
2nd July 2015 - New research
ANTI-EPILEPTIC IMPROVES WEARING-OFF IN PARKINSON'S DISEASE
Zonisamide, despite being an anti-epileptic, reduced "off" time in Parkinson's Disease during clinical trials. Zonisamide is presently being assessed for use in the treatment of Parkinson's Disease. Zonisamide activates dopamine biosynthesis by increasing the level of mRNA of tyrosine hydroxylase, which is the enzyme responsible for dopamine formation. For more information on zonisamide go to : Zonisamide
To determine the efficacy of zonisamide for the treatment of "off" time in Parkinson's Disease, people with Parkinson's Disease who had wearing-off received a placebo for 4 weeks and were then treated for 12 weeks with either 25mg per day zonisamide, 50 mg per day zonisamide, or placebo, in addition to their previous therapy. The "off" time significantly reduced by 45 minutes when taking 50mg zonisamide per day. Although the incidence of somnolence was just a bit higher for zonisamide, the incidences of other adverse events, including dyskinesia or hallucinations, for zonisamide were comparable to those of only a placebo.
The study provides evidence that confirms the efficacy of zonisamide 50 mg
per day for reduction in "off" time in people with Parkinson's Disease with
25th June 2015 - News release
INHALED L-DOPA - PARKINSON'S DISEASE CLINICAL TRIAL RESULTS
CVT-301 is the name of an inhaled version of L-dopa presently being developed for the treatment of Parkinson's Disease. Clinical trial results demonstrated improved efficacy that was apparent in only 10 minutes. CVT-301 uses the ARCUS inhalation technology, which delivers a reliable and consistent drug dose with a compact, breath actuated inhaler. The inhaled version of L-dopa would be used alongside the use of oral L-dopa.
The clinical trial showed that patients experiencing an OFF episode, treated with either 35mg or 50mg CVT-301, had significantly greater improvements in motor function than patients treated with inhaled placebo. The difference in improvement was already apparent 10 minutes after dosing and was durable for at least an hour, the longest time point at which patients were measured. This enables fast working L-dopa unlike what has ever been seen before.
Both doses of CVT-301 were well tolerated, with no increase relative to placebo in troublesome or non-troublesome dyskinesias during ON periods. The most common adverse events were dizziness, headache and cough. There were no adverse events on cardiovascular or lung function. For more information go to Acorda
Based on the results of the Phase 2b clinical trial, Acorda has initiated a Phase 3 clinical trial in order to assess efficacy that is expected to enroll approximately 345 participants who will take either 50mg, 35mg, or placebo, just as were used in the Phase 2b clinical trial. In order to refer to this article on its own click here
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20th June 2015 - New research
PARKINSON'S DISEASE ASSOCIATED WITH 16 CANCERS
Parkinson's Disease has previously been reported to be associated with a reduced risk of cancer, but has now been found to be associated with an increased risk of 16 types of cancer.
The overall risk of cancer in Parkinson's Disease was found to be 1.58 times the normal likelihood. Those cancers associated with Parkinson's Disease in order of the risk of likelihood are : malignant brain tumors 3.42, melanoma 2.75, bladder cancers 1.99, liver 1.89, uterine 1.83, gastrointestinal tract cancers 1.81, skin cancers (besides melanoma) 1.81, prostate 1.80. gallbladder 1.73, lymphoma or leukemia 1.62, kidney 1.59, stomach 1.59, lung cancers 1.56, pancreas 1.48, colorectal 1.47, cervical 1.36.
Of the 19 types of cancer assessed, Parkinson's Disease was not associated with breast, ovarian, or thyroid cancers but was associated with 16 others. It has not been indicated whether the risk of cancer is as a result of Parkinson's Disease or instead related to it indirectly for other reasons. The increased risk of some cancers is quite marginal.
The cause is only established for melonoma. The reduced ability in Parkinson's Disease to produce L-dopa reduces the capacity to produce melanin. Given that melanin helps to protect skin cells from Ultra Violet induced damage, melanoma is very probably increased in Parkinson's Disease because of the reduced capacity to produce L-dopa in the melanocytes. In other studies the risk of developing melanoma has been found to be even higher.
Reference : JAMA Oncology  June 18 [Epub ahead of print] (Pei-Ying Lin, Shih-Ni Chang, Tzu-Hung Hsiao, Bo-Tsang Huang, Ching-Heng Lin, Pan-Chyr Yang) Complete abstract In order to refer to this article on its own click here
18th June 2015 - News release
NONINVASIVE BRAIN STIMULATOR FOR PARKINSON'S DISEASE
John Hopkins University is developing a non-invasive brain stimulator, called Stimband, for the treatment of Parkinson's Disease. STIMband is a headband shaped device that is placed on the head. It does not require any surgery. For more information go to STIMband brain stimulator
For people in advanced stages of Parkinson's Disease, one treatment option is deep brain stimulation. In this procedure, a surgeon implants thin electrical leads into the region of the brain that controls movement. The leads are connected to a pulse generator, similar to a pacemaker for the heart, that is placed under the skin below the collarbone. This implant sends electrical signals to the brain to help curb symptoms caused by Parkinson's Disease. However, this procedure is really invasive and can take 10 to 15 hours to complete.
STIMband is based on transcranial direct current stimulation in which low-level current is passed through two electrodes placed over the head to tweak the electrical activity in specific areas of the brain. The STIMband prototype, which involves no surgery, enables a patient to activate the battery powered treatment by touching a large easy-to-press button. With patient safety in mind, the prototype delivers current for only 20 minutes daily at a doctor prescribed level. It is inexpensive, safe and relatively easy to administer without any side effects.
It is easy to put on, comfortable to wear and is positioned so that the electrodes remain stable and properly target the motor cortices areas of the brain. The inventors obtained provisional patents covering the design of the device, dubbed the STIMband.
Another Johns Hopkins team is taking over the project in September to further enhance the design and move it closer to patient availability. One addition may be a wireless connection to allow a doctor to adjust a patient's treatment level from a remote location. In order to refer to this article on its own click here
15th June 2015 - New research
THE SENSE-PARK SYSTEM FOR PARKINSON'S DISEASE DIAGNOSIS
The SENSE-PARK System has been developed to enable an objective, continuous and relatively unobtrusive system to monitor Parkinson's Disease. It consists of wearable sensors, three of which are worn during the day and one of them worn at night, a smartphone-based App, and a balance board and computer software. For more information go to SENSE-PARK system
The SENSE-PARK System was tested 24/7 over 12 weeks in a study involving people with Parkinson's Disease. During the first four weeks of the study, patients did not get feedback about their performance, during the last eight weeks they did. The study included seven clinical visits with standardised interviews, and regular phone contact. The primary outcome was the number of drop-outs during the study. Yet all patients completed the study.
The participants rated the usability of the SENSE-PARK System favourably. The interviews revealed that most participants liked using the system and appreciated that it signalled changes in their health condition. This study demonstrated that the acceptance level of people with Parkinson's Disease using the SENSE-PARK System as a home-based 24/7 assessment is very good. Motivation to use the system can be increased by providing feedback about the health condition.
Reference : BMC Neurology  15 : 89 (J.J.Ferreira, C.Godinho, A.T.Santos, J. Domingos, D.Abreu, R.Lobo, N.Gonçalves, M.Barra, F.Larsen, Ø.Fagerbakke, I.Akeren, H. Wangen, J.A.Serrano, P.Weber, A.Thoms, S.Meckler, S.Sollinger, J.van Uem, M.A.Hobert, K.Maier, H.Matthew, T.Isaacs, J.Duffen, H.Graessner, W.Maetzler) Complete abstract In order to refer to this article on its own click here
3rd June 2015 - New book
PARKINSON'S DISEASE AND MOVEMENT DISORDERS
Dr. Joseph Jankovic, Eduardo Tolosa
Publisher's description : Trusted as the leading text in the field, Parkinson's Disease and Movement Disorders, 6th Edition, brings you fully up to date with new developments in this rapidly-changing subspecialty. International experts provide thorough coverage of basic science and clear guidance for your day-to-day clinical challenges – from innovative medical and surgical treatments to new drug delivery systems and recent discoveries in genetics, plus much more. In addition, an extensive online video atlas demonstrates movement and posture abnormalities, as well as unique and unusual phenomenology. Click here for more details For more books concerning Parkinson's Disease go to Parkinson's Disease books In order to refer to this article on its own click here
30th May 2015 - New research
CARBON MONOXIDE GREATLY INCREASES THE RISK OF PARKINSON'S DISEASE
Carbon monoxide poisoning has been found to be able to greatly increase the risk of Parkinson's Disease. Common sources of carbon monoxide include cigarette smoke, gas cookers, gas fires, vehicle exhaust, gasoline-powered tools. For more information go to Carbon monoxide
The overall prevalence of Parkinson's Disease (per 100,000 people per year) in those people that had suffered carbon monoxide intoxication was 27.4. After this figure was adjusted for age, sex, and comorbidities, those people that had carbon monoxide intoxication had nine times the normal risk of developing Parkinson's Disease. This makes it one of the most potent uncommon causes of Parkinson's Disease. Those people with carbon monoxide intoxication who were receiving hyperbaric oxygen therapy, which is used to treat carbon monoxide poisoning had a risk of Parkinson's Disease 14 times above normal. The therapy does not cause Parkinson's Disease but instead shows that it is used in more extreme cases.
The risk of Parkinson's Disease increased a lot in those people suffering carbon monoxide intoxication. The significance was increased in young people. Therefore, in some people, carbon monoxide intoxication can be a serious factor leading to Parkinson's Disease.
26th May 2015 - New research
SWEDD IN PEOPLE WITH PARKINSON'S DISEASE
Parkinson's Disease can usually be diagnosed conclusively using scanning methods such as the SPECT scan and the PET scan. The term SWEDD (scans without evidence for dopaminergic deficit) refers somebody initially being assumed to have Parkinson's Disease but whose scan shows the absence of any dopamine deficiency or imaging abnormality that would diagnose them as actually having Parkinson's Disease. For more information go to : SWEDD
While many authors have suggested that medical disorders similar to Parkinson's Disease may account for a proportion of SWEDD cases, others claim that some of them may have a benign subtype of Parkinson's Disease.
There has consequently been some controversy and confusion concerning this term. Researchers systematically reviewed all the studies involving patients with SWEDD with the aim of shedding light on what these patients actually have. After an analysis of all the studies it becomes clear that while most SWEDD cases are due to a clinical misdiagnosis of Parkinson's Disease, there exists a small proportion of patients with SWEDD who may have Parkinson's Disease on the basis of : a positive L-dopa response, clinical progression, imaging and genetic evidence. The latter challenge the seemingly incontrovertible relationship between dopaminergic tracer binding and the diagnosis of Parkinson's Disease.
Reference : Journal of Neurology, Neurosurgery and Psychiatry  May 19 [Epub ahead of print] (R.Erro, S.A.Schneider, N.P.Quinn, K.P.Bhatia) Complete abstract In order to refer to this article on its own click here
21st May 2015 - New research
THE PLACE OF DEATH IN PARKINSON'S DISEASE
Most people prefer to receive end-of-life care in familiar surroundings rather than in hospital. This study examined the variation in the place of death for people dying from Parkinson's disease in European and non-European countries. They used death certificates for deaths with Parkinson's Disease as an underlying cause.
The proportion of deaths in hospital ranged from 17% in the USA, which was the lowest, to 75% in South Korea, which was the highest. Hospital was the most prevalent place of death in France (40%), Hungary (60%) and South Korea (75%). Nursing homes were the most prevalent place of death in New Zealand (71%), Belgium (52%), USA (50%), Canada (48%) and Czech Republic (44%). Home was the most prevalent place of death in Mexico (73%), Italy (51%) and Spain (46%). The chances of dying in hospital were consistently higher for men (Belgium, France, Italy, USA, Canada), those younger than 80 years (Belgium, France, Italy, USA, Mexico), and those living in areas with a higher provision of hospital beds (Italy, USA).
In several countries a substantial proportion of deaths from Parkinson's Disease occurs in hospitals, although this may not be the most optimal place of terminal care and death. The wide variation between countries in the proportion of deaths from Parkinson's Disease occurring in hospital indicates a potential for many countries to reduce these proportions.
Reference : BMC Palliative Care  14 (1) : 28 . [Epub ahead of print] (K.Moens, D.Houttekier, L.Van den Block, R.Harding, L.Morin, S.Marchetti, A.Csikos, M.Loucka, W.A.Naylor, D.M.Wilson, J.Teno, M.Cardenas-Turanzas, Y.Rhee, F.J.Garcia-Leon, L. Deliens, J.Cohen) Complete abstract In order to refer to this article on its own click here
10th May 2015 - New book
PREVENTING PARKINSON'S : HOW TO CUT YOUR RISK BY STRENGTHENING YOUR MULTIPLE SHIELDS
Publisher's description : Preventing Parkinson's is the only book available that gives readers proactive lifestyle recommendations for optimizing health and lowering the risk of developing Parkinson’s Disease. With over 1,000 references, this extraordinary, groundbreaking work provides cutting-edge, evidence-based research. It is a comprehensive compilation that will benefit both lay people and medical professionals alike. Dr. Weinstock thoroughly evaluates how the synergy of diet, exercise, sleep, stress management, avoidance of toxins, prevention of head injuries, and proper medical care can reduce one’s chance of developing Parkinson’s Disease. Click here for more details For more books concerning Parkinson's Disease go to Parkinson's Disease books In order to refer to this article on its own click here
30th April 2015 - New research
NEW GENETIC CAUSE OF PARKINSON'S DISEASE
A new genetic cause of Parkinson's Disease has been discovered called CHCHD2. CHCHD2 is associated with the development of Parkinson's Disease. Most genetic causes of Parkinson's Disease do not inevitably cause Parkinson's Disease but make the person affected more likely to develop Parkinson's Disease.
The full name of the genetic cause is : Coiled-coil-helix-coiled-coil- helixdomain containing 2. The gene is on the Chromosome 7p11.2. The function of the gene is to mediate oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression. The researchers do not know how this function inclines somebody towards Parkinson's Disease. The type of inheritance is autosomal dominant, which means that if the abnormal gene is inherited from only one parent you can get the disease. Often, one of the parents may also have the disease. This gene is associated with an increased likelihood of Parkinsons' Disease.
There are now at least 32 known genetic causes of Parkinson's Disease : PARK 1 to 3, PARK 4 to 20, Tyrosine Hydroxylase deficiency, Aromatic L-amino acid decarboxylase deficiency, CHCHD2, CYP2D6, DRD2. DRD3, GLIS1, LINGO1, MAPT, NRA42, PITX3, RIT2, STH. Details of individual genes can freely accessed at the NCBI database
Reference : The Lancet Neurology  14 (3) : 274-282 (M.Funayama, K.Ohe, T.Amo, N.Furuya, J.Yamaguchi, S.Saiki, Y.Li, K.Ogaki, M.Ando, H.Yoshino, H.Tomiyama, K.Nishioka, K.Hasegawa, H.Saiki, W.Satake, K.Mogushi, R.Sasaki, Y.Kokubo, S.Kuzuhara, T.Toda, Y.Mizuno, Y.Uchiyama, K.Ohno, N.Hattori) Complete abstract In order to refer to this article on its own click here
29th April 2015 - News release
BASEBALL LEGEND DIAGNOSED WITH PARKINSON'S DISEASE
Kirk Gibson, the former American baseball player and manager, now aged 57, has been diagnosed with Parkinson's Disease. As a player he won two Baseball World Series.
He said "I have faced many different obstacles in my life, and have always maintained a strong belief that no matter the circumstances, I could overcome those obstacles. While this diagnosis poses a new kind of challenge for me, I intend to stay true to my beliefs. With the support of my family and friends, I will meet this challenge with the same determination and unwavering intensity that I have displayed in all of my endeavors in life. I look forward to being back at the ballpark as soon as possible." For more information go to News release
Kirk Gibson (born in 1957) was drafted by both the Detroit Tigers baseball team and the St. Louis Cardinals (Arizona Cardinals) football team, but he chose baseball. He played Major League baseball for Detroit Tigers (1979-1987), Los Angeles Dodgers (1988-1990), Kansas City Royals (1991), Pittsburgh Pirates (1992), Detroit Tigers (1993–1995). He won the Baseball World Series twice, with the Detroit Tigers in 1984, and the Los Angeles Dodgers in 1988. In the 1988 World Series, despite being injured, he hit a game winning home run. He was subsequently a coach for Detroit Tigers (2003-2005), Arizona Diamondbacks (2007-2010), and a manager for Arizona Diamondbacks (2010-2014) after which he retired from baseball. For more information go to : Kirk Gibson In order to refer to this article on its own click here
9th April 2015 - New research
NOCTURIA IN PARKINSON'S DISEASE
Nocturia (often waking at night to urinate) is a frequent complaint in Parkinson's Disease. Researchers aimed to assess the mechanism of nocturia in people with Parkinson's Disease by determining the prevalence of nocturnal polyuria in Parkinson's Disease. Nocturnal polyuria is an increase in urine production in the night but with a decrease in daytime urine production. For more information go to Nocturia
Nocturia was defined as one or more awakenings at night to urinate. Two definitions of nocturnal polyuria were used : NUV33 (33% or more of total urination occurs at night), and NUP90 (nighttime urination exceeds 90ml per hour or more. The prevalence of nocturnal polyuria was 64% according to the NUV33 definition, and 17% according to the NUP90 definition. Among those people with nocturia the prevalence of nocturnal polyuria was 66% according to the NUV33 definition and 21% according to the NUP90 definition. The duration of Parkinson's Disease did not increase the likelihood of nocturia or nocturnal polyuria. However, those people who had Parkinson's Disease who were 70 years old and older were more likely to have both - 72% instead of 55% for those younger than 70. Men had nocturia more frequently - 33% for men and 20% for women.
The prevalence of nocturnal polyuria and nocturia was not higher than in the general population of the same age. This suggests that they occur, not as was thought, because of Parkinson's Disease, but because of the older age that is usually associated with Parkinson's Disease.
3rd April 2015 - New research
MONITORING PARKINSON'S DISEASE USING SMARTPHONES
Smartphones have been assessed for their use in monitoring Parkinson's
Disease. A smartphone (smart phone) is a mobile phone with an advanced
mobile operating system.
For more information go to
Participants then took the smart phones home to perform the five tasks four times a day for a month. Once a week they had a remote visit with a Parkinson's Disease specialist in which a modified (excluding assessments of rigidity and balance) UPDRS was performed. The analyses of the five tasks differed between those people with Parkinson Disease and those people who did not have Parkinson's Disease. There was a high degree of accuracy. In discriminating participants with Parkinson's Disease the mean sensitivity was 96% and the mean specificity was 96%.
Measuring Parkinson's Disease symptoms via a smartphone is highly accurate in distinguishing people with Parkinson's Disease. The researchers conclude that it is therefore feasible and has potential value as a diagnostic support tool.
Reference : Parkinsonism Related Disorders  Mar 7 [Epub ahead of print] (S.Arora, V.Venkataraman, A.Hang, S.Donohue, K.M.Biglan, E.R.Dorsey, M.A.Little) Complete abstract In order to refer to this article on its own click here
22nd March 2015 - News release
PRX002 - NEW IMMUNOTHERAPY FOR PARKINSON'S DISEASE
Prothena Corporation have reported a reduction of Alpha-Synuclein by up to
96% after a single dose of PRX002, which is a new protein immunotherapy for
Parkinson's Disease. Alpha-synuclein has been claimed to cause Parkinson's
Disease. PRX002 is the focus of a worldwide collaboration between Prothena
and Roche. For more information go to the
However, a lot of people with Parkinson's Disease do not accumulate alpha-synuclein. So there is none to get rid of. There is no evidence that Alpha-synuclein is a primary cause of Parkinson's Disease as has been claimed. Most people that have an accumulation of alpha-synuclein in the brain do not have Parkinson's Disease and have other medical disorders instead. L-dopa can readily rid symptoms in most people without affecting alpha-synuclein, thereby proving that the ridding of alpha-synuclein in the brain is not needed in order to rid Parkinson's Disease. In order to refer to this article on its own click here
12th March 2015 - New research
EARLY WARNING SIGNS OF PARKINSON'S DISEASE
Researchers assessed the association between the first presentation of
prediagnostic features and a subsequent diagnosis of Parkinson's Disease.
Those symptoms considered were motor features (tremor, rigidity, balance
impairments, neck pain or stiffness, and shoulder pain or stiffness),
autonomic features (constipation, hypotension, erectile dysfunction, urinary
dysfunction, and dizziness), neuropsychiatric disturbances (memory problems,
late-onset anxiety or depression, cognitive decline, and apathy), and
additional features (fatigue, insomnia, anosmia, hypersalivation and
rapid-eye-movement sleep behaviour disorder). Apathy, REM sleep disorder,
anosmia, hypersalivation, and cognitive decline were excluded because they
were infrequently reported.
26th February 2015 - New books
ENCYCLOPEDIA OF PARKINSON'S DISEASE (8 volumes)
Encyclopedia of Parkinson's Disease is an 8 volume series of encyclopedias covering all different aspects of Parkinson's Disease including : etiology, pathphysiology, clinical aspects, diagnosis, rehabilitation, models and modules, therapeutics, novel treatments, advanced therapies. It is certainly the most extensive encyclopedia of Parkinson's Disease.
23rd February 2015 - New research
EFFECT OF RESISTANCE TRAINING ON PARKINSON'S DISEASE
Resistance training is any exercise that causes the muscles to contract
against an external resistance with the expectation of increases in
strength, tone, mass, and/or endurance. The external resistance can be
weights, dumbbells, your own body weight, or any other objects that are
heavy enough to cause the muscles to contract. For more information go to
This review demonstrated that moderate intensity progressive resistance training, 2 to 3 times per week over 8 to 10 weeks, can result in significant strength, balance and motor symptom gains in people with early to moderate Parkinson's Disease.
19th February 2015 - New research
EFFECTS OF TRANSCRANIAL MAGNETIC STIMULATION ON PARKINSON'S DISEASE
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive
technique that relies on electromagnetic induction using an insulated coil
placed over the scalp. The coil generates brief magnetic pulses, which pass
easily and painlessly through the skull into the brain. When pulses are
administered in rapid succession, it is referred to as "repetitive TMS" or
"rTMS", which can produce longer lasting changes in brain activity.
more information go to :
Transcranial magnetic stimulation
However, results evaluating the effectiveness of rTMS in
Parkinson's Disease are mixed. So an assessment was made of all studies
concerning the use of rTMS in Parkinson's Disease.
18th February 2015 - New book
PARKINSON'S DISEASE (DISEASES AND DISORDERS)
Publisher's description : This title in Lucent's Diseases and Disorders series focuses on Parkinson's Disease. The book describes how the disease is contracted, its symptoms, and treatments. It also discusses the issues that caregivers face. These books offer readers a means of understanding various ailments; clear, careful explanations offer insight into what these conditions are, what causes them, how we cope with them, and the latest information about treatment and prevention. All volumes in the series include primary and secondary quotations, annotated bibliographies, detailed indexes, and lists of organizations to contact for additional information Click here for more details For more books concerning Parkinson's Disease go to Parkinson's Disease books In order to refer to this article on its own click here
14th February 2015 - New research
ELTOPRAZINE REDUCES DYSKINESIA IN PARKINSON'S DISEASE
Eltoprazine has been found to reduce L-dopa induced dyskinesias in
Parkinson's Disease. Eltoprazine is a 5HT partial agonist being developed by
Amarantus for the treatment of L-dopa induced dyskinesias in Parkinson's
Disease, Attention Deficit Hyperactivity Disorder and Cognition.
Simultaneous activation of 5-HT1A and 5-HT1B receptors effectively blocked
L-dopa induced dyskinesias in animal models, thereby suggesting its use in
more information go to :
Reference : Brain  Feb 10 [Epub ahead of print] (P.Svenningsson, C.Rosenblad, K.Af Edholm Arvidsson, K.Wictorin, C.Keywood, B.Shankar, D.A.Lowe, A.Björklund, H. Widner) Complete abstract In order to refer to this article on its own click here
11th February 2015 - New research
APDM MOBILITY LAB FOR PARKINSON'S DISEASE ASSESSMENT
The diagnosis and estimation of disease severity in Parkinson's Disease was
assessed using the APDM Mobility Lab. The APDM Mobility Lab uses wearable
sensors and sophisticated signal processing to track even subtle changes in
gait, stride, balance, rotation, and efficiency and range of movement in
upper and lower limbs and torsos. Sensors are simply strapped on to the
subject on various parts of the body, including the chest, waist, wrists and
ankles. Subjects then perform a test after which a report is generated. For
more information go to :
APDM Mobility Lab
The study identified sets of iTUG and iSway variables that correlate with Parkinson's Disease severity measures and differentiate people with Parkinson's Disease. The authors suggest that these gait and balance measures could therefore potentially serve as markers of Parkinson's Disease progression. They are consequently under evaluation for this purpose in the ongoing NIH Parkinson Disease Biomarker Program.
Reference : Journal of Neurological Science  345 (1-2) : 131-138 (D.C.Dewey, S. Miocinovic, I.Bernstein, P.Khemani, R.B.Dewey, R.Querry, S.Chitnis, R.B.Dewey Jr) Complete abstract In order to refer to this article on its own click here
23rd January 2015 - New research
RELUCTANCE TO START PARKINSON'S DISEASE TREATMENT
The first study to assess the reluctance to start medication in Parkinson's
Disease has found a reluctance to begin medication that is primarily due to
a fear about side effects and a refusal to accept a diagnosis of Parkinson's
People with Parkinson's Disease and physicians therefore clearly have a very different perspective on the issue of reluctance to start medication. The researchers suggest that there is a need to bring physicians and patients with Parkinson's Disease closer to a shared vision of the problem reluctance to start medication.
Reference : Parkinsonism Related Disorders  20 (6) : 608-612 (T.A.Mestre, T. Teodoro, W.Reginold, J.Graf, M.Kasten, J.Sale, M.Zurowski, J.Miyasaki, J.J.Ferreira, C. Marras) Complete abstract In order to refer to this article on its own click here
18th January 2015 - New research
HYDROCARBONS INCREASE THE RISK OF PARKINSON'S DISEASE
Exposure to hydrocarbons has been found to significantly increase the
likelihood of developing Parkinson's Disease. This was based on by far the
largest assessment of its kind. Prior to this study there had not been a
consensus concerning hydrocarbons as a cause of Parkinson's Disease.
People with Parkinson's Disease were assessed according to several factors including their previous working exposure to hydrocarbons. Thirteen case controlled studies were made use of in assessing the likelihood of developing Parkinson's Disease. Hydrocarbon exposure increased the likelihood of Parkinson's Disease by 1.32 times normal. Occupational exposure of hydrocarbons increased the likelihood of developing Parkinson's Disease to 1.61 times normal. The biochemical cause of the association was not proposed.
This systematic review supports a positive association between hydrocarbon exposure and Parkinson's Disease. In some people the likelihood of devloping Parkinson's Disease was four times normal. A more emphatic relationship may have been obtained if the degree of exposure was also considered.
Reference : Parkinsonism Related Disorders  Dec 26 [Epub ahead of print] (O.Palin, C.Herd, K.E.Morrison, A.C.Jagielski, K.Wheatley, G.N.Thomas, C.E.Clarke) Complete abstract In order to refer to this article on its own click here
10th January 2015 - New research
DUAL RELEASE L-DOPA APPROVED FOR PARKINSON'S DISEASE
Rytary, which is produced by Impax, has been approved by the FDA (in the USA) for use in the treatment of Parkinson's Disease. Impax expects Rytary to be available for use in February 2015. Most forms of L-dopa are either immediate release, which can cause an excessive effect, or controlled release, which can be slow to start having effect. Rytary is advantageous due to including both immediate release and prolonged release L-dopa.
Rytary can also be used for post-encephalitic parkinsonism, and
parkinsonism that may follow carbon monoxide intoxication or manganese
intoxication. Rytary is designed to address one of the most significant
unmet needs for patients living with Parkinson's disease, which is to reduce
the amount of time during the day when their symptoms are not adequately
In advanced Parkinson's Disease Rytary reduced the percentage of "off" time (by 37% to 23%) when compared to immediate-release carbidopa-levodopa. The most common adverse reactions with Rytary (in at least 5% of patients and more frequently than in placebo) were nausea, dizziness, headache, insomnia, abnormal dreams, dry mouth, dyskinesia, anxiety, constipation, vomiting, and orthostatic hypotension. The most common adverse reactions in advanced Parkinson's Disease were nausea and headache. For more information go to the News Release for 08 Jan 2015 News release In order to refer to this article on its own click here
1st January 2015 - New research
CLINICAL TRIALS OF SUBCUTANEOUS L-DOPA
NeuroDerm has announced results of Phase IIa pharmacokinetic Study of ND0612H and ND0612L. They led to clinically-significant plasma levels of L-dopa. ND0612 is a combination of L-dopa and carbidopa in a liquid formula administered continuously sub-cutaneously through a patch pump. ND0612 is designed to provide steady L-dopa blood levels for the reduction of motor complications in Parkinson's Disease. There is a high dose form ND0612H. For more information go to ND0612H There is a low dose form of ND0612 called ND0612L. For more information go to ND0612L
L-dopa plasma levels were found to be proportionate to the dose. ND0612H achieved maximum daytime concentrations of 1,333ng/ml and 1,436ng/ml. With oral entacapone the levels were even higher, at 1,807ng/ml. ND0612L achieved lower maximum daytime concentrations of 528ng/ml and 477ng/ml. With oral entacapone the L-dopa levels were slightly higher, at 596ng/ml. Fluctuations in L-dopa plasma levels were markedly reduced when compared with oral L-dopa. Treatment with ND0612L and ND0612H did not raise safety and tolerability concerns, causing only minimal and transient local reactions at the infusion site. Due to the short half-life of oral L-dopa, patients are required to take multiple L-dopa doses daily. This results in sharp fluctuations in L-dopa levels which are associated with erratic "off" and "on" periods experienced by many patients.
Continuous sub-cutaneous L-dopa administration using ND0612 can overcome this limitation without having to undergo invasive surgical procedure. For more information go to Neuroderm In order to refer to this article on its own click here
28th December 2014 - New research
EFFECT OF PRAMIPEXOLE ER FOR PARKINSON'S DISEASE
The long term use of pramipexole as a once-daily extended-release oral formulation in early or advanced Parkinson's Disease demonstrated efficacy, but also adverse events. Pramipexole is a dopamine agonist that is most widely sold as Mirapex ER. For more information go to : Mirapex ER
early Parkinson's Disease the main adverse events of extended release
pramipexole were somnolence (15%), peripheral edema (11%) and back pain
(10%). In advanced Parkinson's Disease the main adverse events were
dyskinesia (27%) and somnolence (13%).
These results support the long-term efficacy of pramipexole ER in early and advanced Parkinson's Disease. Adverse Events were typical for dopaminergic medications. UPDRS (Parkinson's Disease) scores suggested sustained symptomatic benefit.
Reference : European Journal of Neurology  21 (5) : 736-743 (R.A.Hauser, A.H. Schapira, P.Barone, Y.Mizuno, O.Rascol, M.Busse, C.Debieuvre, M.Fraessdorf, W.Poewe) Complete abstract In order to refer to this article on its own click here
27th December 2014 - New book
NON-MOTOR SYMPTOMS OF PARKINSON'S DISEASE
K.Ray Chaudhuri, Eduardo Tolosa, Anthony H.V.Schapira, Werner Poewe
Publisher's description : Patients with Parkinson's disease (PD) are known to suffer from motor symptoms, but also experience non-motor symptoms (NMS) that are often present before diagnosis or that inevitably emerge with disease progression. The motor symptoms of Parkinson's disease have been extensively researched, and effective clinical tools for their assessment and treatment are readily available. Researchers have recently begun to focus on the NMS of Parkinson's Disease, which are poorly recognized and inadequately treated. NMS have an impact on patient quality of life and mortality and include neuropsychiatric, sleep-related, autonomic, gastrointestinal, and sensory symptoms. Some NMS can be improved with available treatments, but others will require research into novel therapies. This new edition summarizes the current understanding of NMS in Parkinson's disease and future research. Click here for more details For more books concerning Parkinson's Disease go to Parkinson's Disease books In order to refer to this article on its own click here
22nd December 2014 - New research
LONG TERM EFFECTS OF DBS ON PARKINSON'S DISEASE
Deep Brain Stimulation of the Subthalamic Nucleus (STN-DBS) is an effective treatment for Parkinson's Disease, but in the long term Parkinson's Disease symptoms have been found to still deteriorate very significantly. DBS involves the use of electrodes that are implanted into the brain and connected to a small electrical device called a pulse generator that can be externally programmed. For more information go to : Deep Brain Stimulation
After 11 years, DBS significantly improved the motor symptoms of people with Parkinson's Disease by 35%. Motor complications were well controlled, with an 84% improvement of dyskinesias and a 65% improvement of motor fluctuations. Despite this, the Parkinson's Disease symptom score (the UPDRS-II-on score) worsened by 88%, mainly for the worsening of poorly L-dopa-responsive symptoms. More than 70% of the patients performed in the normal range in most of the neuropsychological tests, despite the development of dementia in 22% of them.
The study confirmed the long-term safety of STN-DBS in Parkinson's Disease. However, the functionality of patients worsens over time, mainly for the onset and progression of L-dopa-resistant and non-motor symptoms. The role of PD-subtype seems to be relevant in the long-term outcome.
Reference : Parkinsonism Related Disorders  20 (4) : 376-381 (M.G.Rizzone, A. Fasano, A.Daniele, M.Zibetti, A.Merola, L.Rizzi, C.Piano, C.Piccininni, L.M.Romito, L. Lopiano, A.Albanese) Complete abstract In order to refer to this article on its own click here
12th December 2014 - New research
AMPHETAMINES INCREASE THE RISK OF PARKINSON'S DISEASE
Previous neurotoxicity findings raised concerns that Amphetamines and Methamphetamines might damage dopaminergic neurons, resulting in dopamine-related medical disorders such as Parkinson's Disease. However, despite widespread use of methamphetamines and other amphetamine type stimulants little was known about the long-term medical consequences of their abuse and dependence.
A retrospective design was used to examine medical records from 1996 until 2011. Patients were divided between (1) Amphetamine and Methamphetamine users, (2) Cocaine users, (3) those people that have not been exposed to drugs or alcohol. They were assessed to see if they were at an increased risk of developing either (1) Parkinson's Disease, or (2) Parkinson's Disease / Parkinsonism / Essential Tremor when compared to people that did not take drugs. In Methamphetamine and Amphetamine users there was a nearly three fold increased risk of Parkinson's Disease, thereby indicating them as a cause of Parkinson's Disease. However, Cocaine users did not show any elevated risk of Parkinson's Disease.
The greatly increased likelihood of developing Parkinson's Disease probably occurs because of the long term effect of amphetamines on the dopamine receptors, which they affect.
Reference : Drug and Alcohol Dependence  Nov 16 [Epub ahead of print] (K.Curtin, A.E.Fleckenstein, R.J.Robison, M.J.Crookston, K.R.Smith, G.R.Hanson) Complete abstract In order to refer to this article on its own click here
7th December 2014 - New research
SIGNS OF PARKINSON'S DISEASE BEFORE DIAGNOSIS
By the time somebody has been diagnosed with Parkinson's Disease many people have already had Parkinson's Disease for years or have had symptoms that were progressing towards it.
Researchers compared those symptoms before diagnosis to their subsequent diagnosis. Those symptoms assessed were : motor features (tremor, rigidity, balance impairments, neck pain or stiffness, and shoulder pain or stiffness), autonomic features (constipation, hypotension, erectile dysfunction, urinary dysfunction, and dizziness), neuropsychiatric disturbances (memory problems, late-onset anxiety or depression, cognitive decline, and apathy), and fatigue, insomnia, anosmia, hypersalivation and REM sleep disorder) prior to diagnosis.
At 10 years before diagnosis the incidence of tremor was many times higher and constipation was higher in those who went on to develop Parkinson's Disease. At 5 years before diagnosis those who went on to develop Parkinson's Disease had a much higher incidence of tremor, a higher incidence of imbalance, constipation, hypotension, and a slightly higher incidence of erectile dysfunction, urinary dysfunction, dizziness, fatigue, depression, and anxiety. At 2 years before diagnosis the incidence of all studied features except neck pain or stiffness was higher in people who went on to develop Parkinson's Disease.
A range of symptoms can therefore be detected years before diagnosis of Parkinson's Disease, with tremor being especially common prior to diagnosis.
2nd December 2014 - New research
SONOGRAPHY FOR DIAGNOSIS OF PARKINSON'S DISEASE
Transcranial sonography is a non-invasive diagnostic technique that makes use of sound waves to create a digital image to aid the diagnosis of Parkinson's Disease.
The sound waves are typically produced by a transducer. Strong, short electrical pulses from the ultrasound machine make the transducer ring at the desired frequency. Materials on the face of the transducer enable the sound to be transmitted efficiently into the body. The sound wave is partially reflected from layers between different tissues. Sound is reflected anywhere there are density changes in the body. Some of the reflections return to the transducer. The return sound wave vibrates the transducer, which turns the vibrations into electrical pulses that travel to the ultrasonic scanner where they are processed and transformed into a digital image. For more information go to Transcranial Sonography
The primary area of the brain concerning Parkinson's Disease is the substantia nigra. The substantia nigra echogenic area was found to be larger in those people with Parkinson's Disease. Substantia nigra echogenicity was also larger in males than in females. Age did not correlate with substantia nigra echogenicity in any group. After multivariate analysis, only the substantia nigra hyperechogenicity was associated with the diagnosis of Parkinson's Disease. Transcranial sonography consequently showed good diagnostic validity for the diagnosis of Parkinson's Disease. However, in a previous study the diagnostic accuracy in the early stages of Parkinson's Disease was not sufficient for routine clinical use.
Reference : Journal of Ultrasound in Medicine  33 (12) : 2069-2074 (A.Alonso- Cánovas, J.L.López-Sendón, J.Buisán, A.deFelipe-Mimbrera, M.Guillán, N.García-Barragán, I.Corral, M.C.Matute-Lozano, J.Masjuan, J.C.Martínez-Castrillo, U.Walter) Complete abstract In order to refer to this article on its own click here
22nd November 2014 - New music
IT'S ALL IN MY HEAD (AN ALBUM ABOUT PARKINSON'S DISEASE)
Publisher's description : This is a music album by a cranky 60-year old with Parkinson’s disease. If there’s one thing that drives him nuts, it’s when people try to cheer him out of his PD doldrums with sappy, silly, “everything’s gonna be FINE!” songs. Everything is NOT going to be fine, not for Bill, and not for the people with this progressive neurological disorder. Still, there’s reason for hope as Bill shares in the last song on this album. People are working day and night to find better treatments and, hopefully, a cure for this beast of a disease. Bill’s album deals with the stuff a person with advanced Parkinson’s disease deals with every day. The feeling that you could be doing more for yourself and easing some of the burden on your caregiver. There’s a lot of snark, sass, sarcasm and sardonic humor in this album. But one thing that comes through is that Bill is not done living. Not just yet. Click here for more details
13th November 2014 - New book
DEEP BRAIN STIMULATION FOR NEUROLOGICAL DISORDERS
Publisher's description : Chronic electrical stimulation of the brain has demonstrated excellent outcomes in patients with Parkinson’s disease and has recently also been applied to other neurological diseases. This comprehensive, up-to-date book will meet the needs of all who wish to learn more about the application of deep brain stimulation and will provide a sound basis for safe and accurate surgery. The book comprises two main parts, the first of which presents relevant anatomical and functional background information on the basal ganglia, thalamus and other brain structures as well as on the mechanism of brain stimulation. The second part describes clinical studies on deep brain stimulation, covering results in a range of movement disorders and psychiatric diseases and also important aspects of instrumentation and technique. The authors are outstanding scientists and experts from across the world. Click here for more details For more books concerning Parkinson's Disease go to Parkinson's Disease books In order to refer to this article on its own click here
8th November 2014 - New research
DELAYING L-DOPA IN PARKINSON'S DISEASE
During the past decade, a number of large drug trials have suggested that the initiation of L-dopa therapy should be delayed in order to reduce the risk of motor complications in people with Parkinson's Disease.
Researchers therefore assessed what happened when L-dopa was withheld for a long time after somebody had developed Parkinson's Disease. They studied Ghana, because in Ghana access to medication for Parkinson's Disease means that initiation of L-dopa is often delayed for many years after the onset of Parkinson's Disease. Their data was compared to people with Parkinson's Disease in Italy, where the use of L-dopa is initiated far earlier. Demographic features, frequency and severity of motor and non-motor symptoms were comparable in the two populations. Although L-dopa therapy was introduced much later in Ghana, the duration of Parkinson's Disease when motor fluctuations and dyskinesias started was similar to people in Italy who initiated the use of L-dopa far earlier.
Instead of how early L-dopa was initiated, what was most associated with motor fluctuations and dyskinesias was (1) the duration of Parkinson's Disease and (2) the daily dose of L-dopa (mg/kg of body weight). The average time to the development of motor fluctuations and dyskinesias after the initiation of L-dopa was surprisingly short as it was only six months.
Reference : Brain  137 (10) : 2731-2742 (R.Cilia, A.Akpalu, F.S.Sarfo, M.Cham, M.Amboni, E.Cereda, M.Fabbri, P.Adjei, J.Akassi, A.Bonetti, G.Pezzoli) Complete abstract
2nd November 2014 - New book
GUIDE TO ASSESSMENT SCALES IN PARKINSON'S DISEASE
Pablo Martinez-Martin, Carmen Rodriguez-Blazquez, Maria Joao Forjaz, Kallol Ray Chaudhuri
Publisher's description : This Guide assesses the key clinimetric attributes in the assessment of Parkinson's Disease, with the intention to offer rapid and pragmatic information on the most relevant scales used. The use of scales for assessment in neurological disorders such as PD arises from the need to quantify disorders and states (such constructs as disability, symptoms, quality of life). Assessment scales are often categorised into two categories: generic (i.e. those scales usable in any health condition), and specific (i.e. scales developed for exclusive use in PD). They can have a variety of components: single-item and multi-item or composite scale; unidimensional and multidimensional; and as disease-centered and patient-centered measures. The creation and validation of scales is complex, with scales undergoing numerous studies to assess criteria such as acceptability, reliability, and responsiveness. Click here for more details For more books concerning Parkinson's Disease go to Parkinson's Disease books In order to refer to this article on its own click here
20th October 2014 - New research
CLINICAL TRIAL RESULTS OF DUAL LAYER L-DOPA
Dual layer L-dopa (IPX066), which is being developed for the treatment of
Parkinson's Disease, unusually and advantageously combines the immediate
release version of L-dopa with the controlled release version of L-dopa. An
application by Impax is with the FDA for the marketing of IPX066 as Rytary.
For more information go to
13th October 2014 - New research
AIR POLLUTION AND PARKINSON'S DISEASE
Exposure to air pollution has been implicated as a cause of Parkinson's Disease. The first prominent descriptions of Parkinson's Disease came at the time of the Industrial Revolution when pollution levels escalated. Yet, no prospective study has examined the association between particulate matter and the risk of Parkinson's Disease.
After adjusting for age in months, smoking, region, population density, caffeine and ibuprofen intake, there was found to be no statistically significant associations between exposure to air pollution and the risk of Parkinson's Disease. The relative risk of Parkinson's Disease was 1.08 for pollution particles that were less than 2.5 microns in diameter, 0.92 for pollution particles that were 2.5 to 10.0 microns in diameter, and 0.99 for pollution particles that were more than 10.0 microns in diameter. These likelihoods are little different from what would be expected normally.
There are areas of the world where pollution is definitely a serious cause of Parkinson's Disease. One of the world's highest prevalences of Parkinson's Disease is in the vicinities of ferromanganese plants near Brescia in Italy. Manganese concentrations in settled dust were found to be significantly higher in the surroundings and downwind from the ferromanganese plants. In high concentrations, manganese is a known cause of Parkinson's Disease.
Reference : Environmental Health  13 (1) : 80 [Epub ahead of print] (N.Palacios, K.C.Fitzgerald, J.E.Hart, M.G.Weisskopf, M.A.Schwarzschild, A.Ascherio, F.Laden) Complete abstract
10th October 2014 - New research
TWENTY YEARS WITH PARKINSON'S DISEASE
Having Parkinson's Disease for more than twenty years has been found to be associated with major milestones of disease disability, fractures, or being confined to a wheelchair or bed. There are a very limited number of studies on the clinical features of Parkinson's Disease twenty years after onset. So an assessment was carried out for several years on people who had Parkinson's Disease for more than twenty years
Those people considered were those who had Parkinson's Disease for 20 to 22 years. They were assessed for an average of nearly four years. Older age at onset and longer duration of Parkinson's Disease were each associated with a higher prevalence of major motor and non-motor milestones of disease disability. Confinement to a wheelchair or bed had by then occurred in just over 1 in 5 people (21%). Those factors making confinement to a wheelchair or bed were older age, postural instability and institutionalisation. Fractures occurred in 16% of people. Fractures were associated with postural instability.
The most frequent outcome was death (28%). However, given the age of diagnosis and the duration of Parkinson's Disease this might have been no more than normal. Mortality was associated with male gender, older age, dysphagia (difficulty in swallowing), orthostatic hypotension, postural instability, fractures and institutionalisation.
Reference : Journal of Neurology, Neurosurgery and Psychiatry  Oct 3 [Epub ahead of print] (R.Cilia, E.Cereda, C.Klersy, M.Canesi, A.L.Zecchinelli, C.B.Mariani, S.Tesei, G.Sacilotto, N.Meucci, M.Zini, C.Ruffmann, I.U.Isaias, S.Goldwurm, G.Pezzoli) Complete abstract In order to refer to this article on its own click here
8th October 2014 - New book
LEVODOPA-INDUCED DYSKINESIA IN PARKINSON'S DISEASE
Susan H.Fox (Editor), Jonathan M.Brotchie (Editor)
Publisher's description : This book aims to provide a single reference source on levodopa-induced dyskinesias (LID) from ‘bench to bedside’. Initial chapters review the clinical features and phenomenology of LID with video examples; epidemiology and genetic risk factors for LID are covered as a background to understanding risk factors for developing LID. The chapters cover the latest preclinical studies aiming to understand the pathophysiology of LID at the cellular, neurochemical, neurophysiological and circuitry level with detailed discussion of mechanisms and future directions to take the field forward; clinical studies from phase II to phase IV; on going RCTs in LID and evidence-based medicine reviews of treatment options. Levodopa-Induced Dyskinesia in Parkinson’s Disease is aimed at an international audience of movement disorder neurologists; neuroscientists; trainees and graduate and post-graduate students. Click here for more details In order to refer to this article on its own click here For more books concerning Parkinson's Disease go to Parkinson's Disease books
5th October 2014 - New research
HANDEDNESS AND PARKINSON'S DISEASE SYMPTOMS
Whether somebody with Parkinson's Disease is right handed or left handed has
been found to greatly affect the side on which their Parkinson's Disease
symptoms initiate and persist.
Out of those people with Parkinson's Disease, 92% were right handed. Nearly 62% of them had an initial onset of symptoms on the right hand side. Out of those people with Parkinson's Disease, 8% were left handed. Around 75% of them had an initial onset of symptoms on the left hand side. Out of those people with Parkinson's Disease who were right handed 77% had Parkinson's Disease symptoms that were dominant on the right hand side. Out of those people with Parkinson's Disease who were left handed 58% of them had Parkinson's Disease symptoms that were dominant on the left hand side.
In general, the dominant side of Parkinson's Disease symptoms was in accordance with which handed they were. In people who were right handed, rest tremor was the most common initial symptom. In people who were left handed, rest tremor and rigidity and bradykinesia were the most common initial symptoms. In order to refer to this article on its own click here Reference : Medicina Clinica  142 (4) : 141-144 (J.Shi, J.Liu, Q.Qu) Complete abstract
1st October 2014 - New research
HORMONES CAN INCREASE THE RISK OF PARKINSON'S DISEASE
ParkinsonismMovement Disorders  Sep 25 [Epub ahead of print] (J.I.Lundin, T.G.Ton, A.Z. LaCroix, W.T.Longstreth, G.M.Franklin, P.D.Swanson, T.Smith-Weller, B.A.Racette, H. Checkoway) Complete abstract
Certain types of commonly used oral contraceptives have been found to greatly increase the risk of developing Parkinson's Disease. Oral contraceptives, which includes estrogen and progestin, are a class of drugs widely prescribed to women. For more information go to Oral contraceptives
Oral contraceptive use by people with Parkinson's Disease were classified as conjugated estrogens, esterified estrogens, or progestin. Ever having used a hormone therapy formulation demonstrated a suggested elevated risk with esterified estrogen use that was three times the normal. However, there was no increase in the risk of developing Parkinson's Disease in those people who had taken conjugated estrogen. Restricting this analysis to prescriptions that included progestin greatly increased the risk associated with esterified estrogen use, making Parkinson's Disease SEVEN times more likely. Progestin also moderately increased the risk of developing Parkinson's Disease in those people who taken conjugated estrogen.
The findings from this study suggest a great increase in Parkinson's Disease risk associated with the use of esterified estrogen combined with progestin, but no risk is associated with conjugated estrogen on its own. In order to refer to this article on its own click here
28th September 2014 - New research
WEARING OFF IN PARKINSON'S DISEASE
Parkinsonism Related Disorders  20 (2) : 204-211 (F.Stocchi, A.Antonini, P.Barone, M.Tinazzi, M.Zappia, M.Onofrj, S.Ruggieri, L.Morgante, U.Bonuccelli, L.Lopiano, P. Pramstaller, A.Albanese, M.Attar, V.Posocco, D.Colombo, G.Abbruzzese) Complete abstract
Wearing off of the effect of drugs for Parkinson's Disease has been found to occur far earlier and in more people with Parkinson's Disease than previously assumed. Wearing off is very individual and there is no standard time frame for when this may occur or which symptoms are experienced. For more information go to Wearing off
Neurologists found that there was wearing off in 57% of people with Parkinson's Disease. However, when this was assessed by the patients themselves, there was found to be wearing off in 67% of people with Parkinson's Disease. Even in people who had Parkinson's Disease for less than 2.5 years there was wearing off in 21% of people when assessed by neurologists and in 41% when patients assessed themselves. The most frequent wearing off symptoms were slowness of movements (55%) and reduced dexterity (48%). Those factors most associated with wearing off were : younger age, female gender, severer symptoms, and duration of treatment.
Wearing Off is already common in the early stages of Parkinson's Disease and is underestimated by routine neurological clinical evaluation. The effect of Parkinson's Disease drugs is therefore often relatively short lived. In order to refer to this article on its own click here
25th September 2014 - New Audiobook
PUT ON YOUR PARKY FACE ! THE EXPANDED VERSION
Publisher's description : Put on your Parky face is a narrated Audiobook about Parkinson's Disease by widely known Parkinson's Disease blogger Bill Schmalfeldt. Bill is serving notice. It's time for Parkinson's disease patients to stop being invisible. It's time for a nationwide effort to raise awareness about this crippling degenerative neurological disorder and the havoc it wreaks. Having had Parkinson's Disease since 2000 at the age of 45, Bill volunteered for experimental brain surgery in 2007. He spins a humorous, poignant, and sometimes angry tale about his life with this progressive neurological condition. He uses his time, focus and energy to help fund the research that will find the cure. 100% of the author proceeds from this book will be donated to Parkinson's research charities. On the web site there is a good audio sample. Click here for more details In order to refer to this article on its own click here
19th September 2014 - New research
TOZADENANT CLINICAL TRIALS FOR PARKINSON'S DISEASE
Lancet Neurology  13 (8) : 767-776 (R.A.Hauser, C.W.Olanow, K.D.Kieburtz, E. Pourcher, A.Docu-Axelerad, M.Lew, O.Kozyolkin, A.Neale, C.Resburg, U.Meya, C.Kenney, S.Bandak) Complete abstract
Clinical trials assessed the use 60mg, 120mg, 180mg, or 240mg tozadenant in people with Parkinson's Disease who were being treated with L-dopa and who had motor fluctuations that involved at least 2·5 hours off-time per day. Tozadenant (SYN115) is an inhibitor of the adenosine 2a (A2a) receptor that is being developed for the treatment of Parkinson's Disease. For more information go to SYN115
Compared with the use of a placebo, daily off-time was reduced by more than an hour when taking either 120mg or 180mg tozadenant. The most common adverse events were dyskinesia (16% of people taking 120mg, 20% of people taking 180mg), nausea (11% of people taking 120mg, 12% of people taking 180mg), dizziness (5% of people taking 120mg, 13% of people taking 180mg). Tozadenant, 60 mg twice daily, was not associated with a significant reduction in off-time. Tozadenant, 240 mg twice daily, was associated with an increased rate of discontinuation because of adverse events that occurred in 20% of people taking that dosage.
The researchers concluded that Tozadenant at 120 or 180 mg twice daily was generally well tolerated and was effective at reducing off-time. Further investigation of tozadenant treatment in phase 3 trials is warranted. In order to refer to this article on its own click here
11th September 2014 - New research
ENTACAPONE EFFICACY IN PARKINSON'S DISEASE
Acta Neurologica Scandinavica  Sep 3 [Epub ahead of print]
(M.Kuoppamäki, M. Vahteristo, J.Ellmén, K.Kieburtz)
8th September 2014 - News release
SUBCUTANEOUS LIQUID L-DOPA FOR PARKINSON'S DISEASE
NeuroDerm have announced that the first patients with severe Parkinson's
Disease have been enrolled and dosed in a Phase IIa trial of ND0612H.
ND0612H is a high-dose form of liquid L-dopa and carbidopa (which is the
same as Sinemet) but which is delivered continuously through subcutaneous
administration (via the skin) by a belt-pump. Unlike the most comparable
methods of administering L-dopa, no surgery at all is needed.
is the low dose drug form intended for moderate Parkinson's Disease. ND0612L
has just completed patient enrolment and treatment in a Phase II
double-blind, randomised, placebo-controlled study. ND0612L was shown in
previous phase I and phase IIa studies to be safe and tolerable, reaching
steady state, clinically meaningful L-dopa blood concentrations.
23rd August 2014 - New book
WINDOW OF OPPORTUNITY : LIVING WITH THE REALITY OF PARKINSON'S AND THE THREAT OF DEMENTIA
Publisher's description : Window of Opportunity is the story of one person's journey through the initial signs of cognitive impairment brought on by Parkinson's disease and how this potentially disabling diagnosis turns into a "Window of Opportunity" to help others on the path. Kirk Hall began noticing small signs of mild cognitive impairment. He tells his story with directness, candor, sensitivity and humor. He describes the long and challenging visits to doctors seeking answers to his disturbing symptoms and the confusion caused by conflicting opinions about the nature and progression of his disease. His journal notes allow him to describe in vivid detail his slowly coming to grips with disability. He shares the internal struggle, anxiety and stress that uncertainty causes, not only for himself but for his family as well. Click here for more details
Kirk W.Hall has also written two children's books concerning Parkinson's Disease - Carina and Her Care Partner Gramma Click here for more details and Carson and His Shaky Paws Grampa Click here for more details
15th August 2014 - News release
ROBIN WILLIAMS DIES WITH PARKINSON'S DISEASE
Robin Williams (1951-2014) was an American actor and comedian who
appeared in numerous films. He recently committed suicide. His wife, Susan
Schneider, has made a statement that, at the time of his death, Robin
Williams was in the early stages of Parkinson's Disease.
14th August 2014 - News release
WEARABLE SENSORS FOR PARKINSON'S DISEASE
The Michael J. Fox Foundation and Intel Corporation are partnering to
gather and analyse data from Wrist-worn devices worn by people with
Parkinson's Disease that track users' movement. The results could help
individuals and their doctors better manage their Parkinson's Disease.
Intel engineers are comparing the data obtained from the device to
clinical observations and patient diaries in order to test the devices'
accuracy. They are developing mathematical formulas to measure the symptoms
and the progression of Parkinson's Disease. These devices can capture up to
300 observations per second. So formulas to interpret all that data and
report what it means related to someone's Parkinson's Disease can help
individuals and their physicians monitor disease.
29th July 2014 - New research
DISCOVERY OF NEW PARKINSON'S DISEASE GENETIC FACTORS
Nature Genetics  (27 July) (M.A.Nalls, N.Pankratz, C.M.Lill,
C.B.Do, D.G. Hernandez, M.Saad, A.L.De Stefano, E.Kara, J.Bras, M.Sharma,
C.Schulte, M.F.Keller, S.Arepalli, C.Letson, C.Edsall, H.Stefansson, X.Liu,
H.Pliner, J.H.Lee, R.Cheng, et al)
They conducted an extensive analysis of Parkinson's Disease genetic studies. Twenty six sites were identified as having a significant genetic association with Parkinson's Disease. These and six additional sites that had previously not been reported were then tested. In total, they identified and replicated 28 independent risk variants for Parkinson's disease across 24 loci (positions on the gene). Although the effect of each individual genetic risk was found to be small, a risk profile analysis showed that there was a substantial cumulative risk of developing Parkinson's Disease because of them. The risk was actually tripled when several genetic risk factors occurred simultaneously.
Their results suggested that the more variants a person has the greater the risk, which is up to three times higher for developing Parkinson's Disease in some cases. Genetic causes of Parkinson's Disease usually make Parkinson's Disease more likely rather than inevitable. Although genetic causes of Parkinson's Disease are uncommon the actual prevalence is unknown. In order to refer to this article on its own click here
27th July 2014 - New research
NASAL DELIVERY OF PARKINSON'S DISEASE TREATMENT
Expert opinion on drug delivery  11 (6) : 827-842 (S.Md, S.Haque, M.Fazil, M. Kumar, S.Baboota, J.K.Sahni, J.Ali) Complete abstract
Researchers evaluated whether prepared nanoparticles would be able to target Parkinson's Disease treatments to the brain via the nasal route, thereby enhancing their bioavailability. They tested the method using an optimised nanoformulation of the dopamine agonist bromocriptine for direct nose-to-brain delivery.
The percentage accuracy observed for intra-day and inter-day batch samples was very high. Bromocriptine was found to be stable in all exposed conditions. Bromocriptine nanoparticles also showed greater retention into the nostrils for about four hours. Direct bromocriptine nanoparticle nose-to-brain transport was shown to then bypass the blood-brain barrier. Most importantly, bromocriptine nanoparticles administered nasally showed significantly high dopamine concentrations.
The researchers concluded that Nanoparticle drug delivery system could be potentially used as a nose-to-brain drug delivery carrier for improving the existing means of treating Parkinson's Disease. In order to refer to this article on its own click here
23rd July 2014 - News release
APOMORPHINE CLINICAL TRIAL FOR PARKINSON'S DISEASE
CTH-105 is a Phase 2 clinical study of APL-130277. APL-130277 will be studied in 16 people with Parkinson's disease who have not used apomorphine and who experience at least one daily "off" episode, with a total duration of "off" in any 24-hour period of at least 2 hours. This open study will examine the effect of APL-130277 on relieving "off" episodes over a single day, with dose-titration used to determine dose strengths necessary for future clinical use.
In particular, the dose strength information is necessary in order to conduct the larger CTH-300a efficacy study in apomorphine naive patients, which is expected to commence at the end of 2014. The primary means of assessment will be the change in the UPDRS III score, which is the most widely used Parkinson's Disease symptom questionnaire. For more information go to Cynapsus In order to refer to this article on its own click here
17th July 2014 - New research
SOCIAL PHOBIAS ARE COMMON IN PARKINSON'S DISEASE
14th July 2014 - New research
MISDIAGNOSIS OF PARKINSON'S DISEASE
Researchers aimed to determine the diagnostic accuracy of a clinical
diagnosis of Parkinson's Disease using neuropathologic diagnosis as the
standard. The accuracy of diagnosis was found to be very poor.
neuropathologic findings of Parkinson's Disease as the standard, this study
established a finding of only 26% accuracy for a clinical diagnosis of
Parkinson's Disease in untreated patients, 53% accuracy in early Parkinson's
Disease of less than five years duration that was responsive to medication,
and 85% diagnostic accuracy in Parkinson's Disease of longer duration that
was medication-responsive. Clinical variables that improved diagnostic
accuracy were medication response, motor fluctuations, dyskinesias, and
hyposmia (reduced sense of smell).ic accuracy in Parkinson's Disease of
longer duration that was medication-responsive.
This study showed that a clinical diagnosis of Parkinson's Disease identifies people who will have pathologically confirmed Parkinson's Disease with a sensitivity of 88% and specificity of 68%. For more information concerning the diagnosis of Parkinson's Disease go to Diagnosis of Parkinson's Disease In order to refer to this article on its own click here
10th July 2014 - New research
ß-ASARONE INCREASES L-DOPA IN PARKINSON'S DISEASE
In order to increase the effect of L-dopa it is usually administered in combination with a dopa decarboxylase inhibitor. In Sinemet, L-dopa is combined with carbidopa. In Madopar, L-dopa is combined with benserazide. The co-administration of ß-asarone and Levodopa is being developed as a means of improving the effect of L-dopa even further.
ß-asarone is found in the flowering plant acorus and also in asarum, which is known as wild ginger. For more information go to Ansarone
In animal studies the use of L-dopa in combination with ß-asarone was
compared to the use of existing methods of treating Parkinson's Disease.
Dopamine levels were found to increase in the brain (in the striatum) and in
blood plasma in response to ß-asarone. The co-administration of ß-asarone
and L-dopa could also increase the levels in blood plasma of tyrosine
hydroxylase, which is the enzyme responsible for the formation of L-dopa.
Altogether, ß-asarone was found to have an effect on converting L-dopa into
dopamine by modulating the activity of dopamine metabolism.
The mechanism of co-administration of ß-asarone and L-dopa is different from that of Sinemet and Madopar in the treatment of Parkinson's Disease. The co-administration of ß-asarone and L-dopa may be more beneficial to Parkinson's Disease treatment than the existing methods and so could eventually replace them. In order to refer to this article on its own click here
5th July 2014 - New research
THE WORLDWIDE PREVALENCE OF PARKINSON'S DISEASE
Researchers sought to synthesize studies on the prevalence of Parkinson's Disease to obtain an overall view of how the prevalence varies by age, gender, and geographic location. Geographic location was stratified by the following groups : Asia, Africa, South America, Europe / North America / Australia. Data were analyzed by age group, geographic location, and gender.
of worldwide data showed a rising prevalence of Parkinson's Disease with
age, with (per 100,000) : 41 in 40 to 49 year olds, 107 in 50 to 59 year
olds, 173 in 55 to 64 year olds, 428 in 60 to 69 year olds, 1087 in 70 to 79
year olds, and 1903 in those aged older than 80.A
significant difference was seen in prevalence geographically only for people
who were 70 to 79 years old, with a prevalence of 1601 (per 100,000) in
people in North America, Europe, and Australia, compared to only 646 (per
100,000) in people from Asia. Differences in prevalence according to gender
was found only for people who were 50 to 59 years old, with a prevalence of
41 in females and 134 in males.
29th June 2014 - New research
COMPARISON OF L-DOPA, AGONISTS AND MAO INHIBITORS
Whether the initial treatment for Parkinson's disease should consist of L-dopa, dopamine agonists, or MAO B inhibitors is uncertain. So researchers aimed to establish which of these three classes of drug, as initial treatment, provided the most effective long-term control of symptoms and best quality of life for people with early Parkinson's Disease.
newly diagnosed with Parkinson's disease were randomly assigned between the
use of L-dopa, dopamine agonists and MAO B inhibitors. After three years
PDQ-39 mobility scores averaged 1·8 points better in people assigned to
L-dopa. PDQ-39 mobility scores were 1·4 points better in people assigned to
MAO B inhibitors when compared to those taking dopamine agonists. L-dopa was
not significantly advantageous for EQ-5D utility scores, dementia,
admissions to institutions, and death rates. Treatments were discontinued in
28% of those taking dopamine agonists, 23% of those taking MAOB inhibitors,
but only 2% of those taking L-dopa.
21st June 2014 - New research
CIRCADIAN RHYTHMS IN PARKINSONS' DISEASE
People with Parkinson's Disease have been found to have blunted circadian rhythms. Circadian rhythms are the alterations of endocrine functions that take place in a regulated manner over a roughly 24 hour period. The pineal gland produces melatonin, which is a hormone that regulates the circadian rhythms. For more information go to Circadian rhythms
differences and the range of secretion of melatonin from the pineal gland
were found to be lower in Parkinson's Disease than in people that do not
have Parkinson's Disease. Overall Parkinson's Disease symptoms and duration
of symptoms were not significantly related to the circadian rhythm. So it
was only daytime sleepiness and not Parkinson's Disease symptoms generally
that are affected by the blunted circadian rhythm that can occur in
Parkinson's Disease. Dopamine regulates melatonin
secretion. Therefore, the reduced dopamine that occurs in Parkinson's
Disease will lead to an altered circadian rhythm.
9th June 2014 - New research
FAHR'S SYNDROME IS A CAUSE OF PARKINSON'S DISEASE
Journal of the College of Physicians and Surgeons - Pakistan  24 (5) : S104-S106 (N.Dildar, H.Akram, I.M.Qasmi, M.N.Qureshi, S.Khan) Complete abstract
Fahr's Syndrome is a rare inherited neurological disorder that can present with a wide spectrum of symptoms, including those of Parkinson's Disease. It is characterised by abnormal deposits of calcium in areas of the brain that control movement, including the basal ganglia and the cerebral cortex. For more information go to Fahr's Syndrome
Symptoms of Fahr's Syndrome that are similar to those of Parkinson's Disease may include deterioration of motor function, dementia, dysarthria (poorly articulated speech), tremors, muscle rigidity, a mask-like facial appearance, shuffling gait, and a "pill-rolling" motion of the fingers. These symptoms generally occur later in the development of the disease.
More common symptoms of Fahr's Syndrome include dystonia (disordered muscle tone) and chorea (involuntary, rapid, jerky movements). The age of onset of Fahr's Syndrome is typically in the 40s or 50s, which is similar to Parkinson's Disease, although it can also occur at any time in childhood or adolescence.
Due to the possible similarity of symptoms to those of Parkinson's Disease, Fahr's Syndrome should be considered as an important differential diagnosis in cases of Parkinsonism. In order to refer to this article on its own click here
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