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DECEMBER 2015

 

31st December 2015 - New research

PRE-MOTOR SYMPTOMS OF PARKINSON'S DISEASE

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Parkinson's disease is characterised by motor and non-motor clinical features. The latter may present as pre-motor symptoms several years before the onset of motor symptoms. Pre-motor symptoms have been found to be associated to a later motor onset of Parkinson's Disease.

The overall frequency of pre-motor symptoms was 76%. Among the most prevalent symptoms were depression (38%), sleep disorders (37%) and anxiety (36%). The time prior to motor onset was greatest for constipation (9 years) and pain (8 years). 
People with more than two pre-motor symptoms had a later age at motor onset when compared to people without pre-motor symptoms (56 v 52). Late onset patients had a higher frequency of pre-motor symptoms (79% v 65% in early onset) and worse symptoms than early onset. Females reported a higher number of pre-motor symptoms (1.9 v 1.4). Anxiety lead-time was greater in tremor-dominant compared to bradykinetic-rigid patients (3 years).

Pre-motor symptoms load is associated to a later motor onset of PD.  Pre-motor symptoms are more frequent in subjects with late onset Parkinson's disease. Female subjects report a higher number of pre-motor symptoms, depression and anxiety being the most common.

Reference : Journal of Parkinson's Disease [2015] Dec 10 [Epub ahead of print] (M.Rodríguez-Violante, A.J.de Saráchaga, A.Cervantes-Arriaga, R.Millán-Cepeda, R.Leal-Ortega, I.Estrada-Bellmann, C.Zuñiga-Ramírez)   Complete abstract  In order to refer to this article on its own click here   

 

30th December 2015 - New book

GOODBYE PARKINSONS, HELLO LIFE !

Alex Kerten, David Brinn

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Publishers description : In Goodbye Parkinson’s, Hello Life! Alex Kerten presents his holistic technique that combines dance therapy, behavior modification, and martial arts, to prove that there is life beyond the diagnosis of PD. Goodbye Parkinson’s, Hello life! received "Recommended Reading" status by the Michael J. Fox Foundation. Those who follow Kerten's techniques and are committed to becoming “Parkinson’s warriors” can succeed in eliminating many of their symptoms and return to a productive and fulfilling life. Instead of viewing themselves as Parkinson's victims, the methods in Goodbye Parkinson’s, Hello life! will lead them to become healthy people with Parkinson's. Includes 20 easy-to-follow exercises. Click here for more details For more books concerning Parkinson's Disease go to Parkinson's Disease books  

 

28th December 2015 - New research

ULTRA EARLY DIAGNOSIS OF PARKINSON'S DISEASE

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Researchers determined the value of enhanced substantia nigra echo in the diagnosis of Parkinson's Disease by analyzing the intensity and area of substantia nigra echo using transcranial Doppler sonography (TCS). Transcranial Doppler sonography is a technique that uses a handheld, microprocessor-controlled, low-frequency, pulsed Doppler transducer to measure the velocity and pulsatility of blood flow within certain areas of the brain. For more information go to :  : Transcranial Doppler Sonography  

People without Parkinson's Disease were compared to people with ultra early stage Parkinson's Disease using results of substantia nigra echo, which are graded I (the least) to V (the greatest). The sensitivity of substantia nigra echo in diagnosing Parkinson's Disease was 89% and the specificity was 93%. The levels were much higher in early Parkinson's Disease. The figures for those people with Parkinson's Disease compared to those who did not have it were Grade V (19% v none), Grade IV (33% v none), Grade III (36% v 6%), Grade II (11% v 40%), Grade I (none v 53%). High grades were only present in Parkinson's Disease. Low grades were only present when there was no Parkinson's Disease.

Analysis of substantia nigra echo is therefore of practical use for the diagnosis of the ultra early stage Parkinson's Disease. It is cheaper and easier than the primary scanning methods and so can potentially improve the accuracy of clinical diagnosis to significantly enhance the early clinical prevention of disability.

Reference : European Review of Medical and Pharmacologial Sciences [2015] 19 (23) : 4621-4626 (J.J.Zhuang, Y.H.Zheng, X.W.Xu, L.Zhou) Complete abstract  In order to refer to this article on its own click here   

 

26th December  2015 - New book

MY DEGENERATION : A JOURNEY THROUGH PARKINSON'S

Peter Dunlap-Shohl

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Publishers description : How does one deal with a diagnosis of Parkinson’s disease at the age of forty-three? My Degeneration, by former Anchorage Daily News staff cartoonist Peter Dunlap-Shohl, answers the question with humor and passion, recounting the author’s attempt to come to grips with the “malicious whimsy” of this chronic, progressive, and disabling disease. This graphic novel tracks Dunlap-Shohl’s journey through depression, the worsening symptoms of the disease, the juggling of medications and their side effects, the impact on relations with family and community, and the raft of mental and physical changes wrought by the malady. Click here for more details For more books concerning Parkinson's Disease go to Parkinson's Disease books  

 

23rd December 2015 - New research

PARKINSON'S DISEASE GENE SUPPRESSES CANCER

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Melanoma incidence is higher in people affected by Parkinson's Disease but the genetic link shared by both diseases was unknown. The Parkin gene (PARK2) is often mutated in Parkinson's Disease and is consequently sometimes a genetic cause of Parkinson's Disease. However, PARK2 is also a tumor suppressor gene both of melanoma predisposition and progression. Melanoma is a form of skin cancer more common in Parkinson's Disease. For more information go to : Melanoma  

The An in-depth analysis of the PARK2 (Parkin) gene showed that mutations were present far more often in Parkinson's Disease, making Parkinson's Disease nearly four times more likely. The formation of the Parkin gene occurs in melanocytes but not in most cells in which there is melanoma. The formation of the Parkin gene in melanoma cell lines resulted in a drastic reduction of cell proliferation. Inhibition of the Parkin gene in melanocytes stimulated their proliferation.

The results show an important role for the Parkin gene (PARK2), not only in Parkinson's Disease, but also as a tumor suppressor both in melanoma predisposition and progression, which could explain the association between Parkinson's Disease and melanoma.

Reference : Journal of the National Cancer Institute [2015] 108 (3) pii : djv340 (H.H.Hu, C.Kannengiesser, S.Lesage, J.André, S.Mourah, L.Michel, V.Descamps, N.Basset-Seguin, M.Bagot, A.Bensussan, C.Lebbé, L.Deschamps, P.Saiag, M.T.Leccia, B.Bressac-de- Paillerets, A.Tsalamlal, R.Kumar, S.Klebe, B.Grandchamp, N.Andrieu-Abadie, L.Thomas, A.Brice, N.Dumaz, N.Soufir)  Complete abstract  In order to refer to this article on its own click here   

 

1st December 2015 - News release

NUMIENT AUTHORISED FOR USE IN PARKINSON'S DISEASE

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Impax Laboratories have received authorisation in the EU for the use of NUMIENT™ (Levodopa and Carbidopa) Modified-Release Capsules for the treatment of Parkinson's Disease.

Numient is the same as Rytary, which is already available in the U.S.. Rytary and Numient are novel and distinct by including immediate release AND extended release versions of L-dopa. The different versions of Sinemet and Madopar include only immediate release OR extended release versions of L-dopa. For more information go to : Medscape

The authorisation is based on the results of Phase 3 clinical trials, which assessed the safety and efficacy in early and advanced Parkinson's Disease. In the primary clinical trial, advanced Parkinson's Disease treatment with IPX066 (NUMIENT) reduced the "off" time, from 36% to 23% compared to 36% to 29% for immediate-release levodopa-carbidopa. IPX066 (NUMIENT) also increased the "on" time without dyskinesias during waking hours by 1.9 hours compared with an increase of 0.8 hours following treatment with immediate-release levodopa-carbidopa.

The most frequently reported adverse reactions were nausea, occurring in approximately 12% of all patients; then dizziness, headache, and dyskinesia, each occurring in approximately 8% of all patients; and insomnia, occurring in approximately 6% of all patients. Serious adverse events from gastrointestinal haemorrhage and allergic oedema were uncommon.  For more information go to : Impax  In order to refer to this article on its own click here

 

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