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AUGUST 2015

 

31st August 2015 - New research

ASTHMA TREBLES THE RISK OF PARKINSON'S DISEASE

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Asthma has been found to treble the likelihood of developing Parkinson's Disease. This risk is multiplied in more severe asthma. Asthma is a common long-term condition that can cause coughing, wheezing, chest tightness and breathlessness. Occasionally, asthma symptoms can get gradually or suddenly worse, causing an "asthma attack". For more information go to : Asthma

From those people that were diagnosed with asthma, those who subsequently developed Parkinson's Disease were identified. Also examined were their asthma severity, as indicated by the frequency of hospital admissions for asthma. People with asthma were found to have an increased risk of developing Parkinson's Disease that was three times normal.

People with more severe asthma who had frequent hospital admissions exhibited a far greater risk of subsequent Parkinson's disease that was as much as 16 times greater than would be expected. Fewer hospital admissions made the likelihood less than this.

The link between asthma and Parkinson's Disease is the level of activity of the cholinergic neurons. Cholinergic activity stimulates muscle contraction, which can provoke the muscular symptoms of Parkinson's Disease. Cholinergic activity also affects the bronchial glands. That is why anti-cholinergic drugs are used for both asthma and Parkinson's Disease.

Reference : Allergy [2015] Aug 27 [Epub ahead of print] (C.M.Cheng, Y.H.Wu, S.J.Tsai, Y.M.Bai, J.W.Hsu, K.L.Huang, T.P.Su, C.T.Li, C.F.Tsai, A.C.Yang, W.C.Lin, T.L.Pan, W.H.Chang, T.J.Chen, M.H.Chen) Complete abstract  In order to refer to this article on its own click here     

 

30th August  2015 - New book

THE NEW PARKINSON'S DISEASE TREATMENT BOOK : PARTNERING WITH YOUR DOCTOR TO GET THE MOST FROM YOUR MEDICATIONS

J. Eric Ahlskog

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Publishers description : Dr. Ahlskog draws on thirty years of clinical experience to present the definitive guide to dealing with all aspects of Parkinson's Disease, from treatment options and side effects to the impact of the disease on caregivers and family. Dr. Ahlskog's goal is to educate patients so that they can better team up with their doctors to do battle with the disease.  This book also examines additional aspects of treatment, such as the role of nutrition, exercise, and physical therapy. Patients are able to make more informed choices, and doctors are able to provide more tailored care. This book delivers extensive information to all parties concerned : patients, caregivers, and doctors.  Click here for more details For more books concerning Parkinson's Disease go to Parkinson's Disease books In order to refer to this article on its own click here

 

12th August 2015 - New research

TRANSDERMAL ROTIGOTINE - CLINICAL TRIAL RESULTS

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Transdermal rotigotine, which is marketed as Neupro, is a dopamine receptor agonist that is used in the treatment of Parkinson's Disease. It offers the potential for continuous dopaminergic stimulation that could avoid the fluctuations observed with traditional forms of dopamine agonists. Neupro provides continuous delivery for 24 hours following application of the patch to intact skin. For more information go to : Neupro and  Transdermal rotigotine system

Rotigotine made hardly any difference to the Non-motor symptom score in Parkinson's Disease. However, improvements were detected in mood and apathy. General symptom improvements and the PDQ-39 scores also favoured rotigotine. Transdermal rotigotine also improved swallowing. There was a significantly greater reduction in the off-time when using rotigotine.

Adverse events reported more frequently with rotigotine were nausea, application site reactions, somnolence and headache. Serious adverse events were only uncommonly reported.

References : European Journal of Neurology [2015] Jun 22 [Epub ahead of print] (A.Antonini, L.Bauer, E.Dohin, W.H.Oertel, O.Rascol, H.Reichmann, M.Schmid, P.Singh, E.Tolosa, K.R.Chaudhuri) Complete abstract

Dysphagia [2015] May 13 [Epub ahead of print] (M.Hirano, C.Isono, H.Sakamoto, S.Ueno, S.Kusunoki, Y.Nakamura) Complete abstract

Journal of Neurology [2014] 261 (10) : 1887-1893 (M.Nomoto, Y.Mizuno, T.Kondo, K.Hasegawa, M. Murata, M. Takeuchi, J.Ikeda, T.Tomida, N.Hattori)  Complete abstract  In order to refer to this article on its own click here

 

5th August 2015 - New research

FROZEN SHOULDER SYNDROME IN PARKINSON'S DISEASE

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Frozen Shoulder Syndrome, which is a common musculoskeletal disease in Parkinson's Disease, has been found to occur at times in nearly half of people with Parkinson's Disease. The shoulder becomes stiff and so greatly restricts movement of the shoulder. It can cause chronic pain and physical disability. For more information go to : Frozen Shoulder Syndrome

Frozen Shoulder Syndrome can more commonly affect people with Parkinson's Disease, with from 12% to 46% of people with Parkinson's Disease being affected. Shoulder problems generally occur far more commonly in Parkinson's Disease. Those prone to Frozen Shoulder Syndrome had initial symptoms of akinesia twice as frequently as tremor. In at least 8% of people with Parkinson's Disease who have Frozen Shoulder Syndrome, frozen shoulder syndrome was even the first symptom, occurring up to 2 years before other common symptoms of Parkinson's Disease. However, the "frozen shoulders" and pain can respond to L-dopa.

Reference : Parkinson's Disease [2015] Jun 9 [Epub 2015] (Y.T.Chang, W.N.Chang, N.W.Tsai, K.Y.Cheng, C.C.Huang, C.T.Kung, Y.J.Su, W.C.Lin, B.C.Cheng, C.M.Su, Y.F.Chiang, C.H.Lu)  Complete abstract  In order to refer to this article on its own click here     

 

2nd August  2015 - New book

DISORDERS OF SLEEP AND CIRCADIAN RHYTHMS IN PARKINSON'S DISEASE

Aleksandar Videnovic, Birgit Högl

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Publishers description : This book is the first to take into account the rapidly growing body of knowledge on the relation between sleep and PD. It provides a unique source of in-depth information on sleep and circadian dysregulation in Parkinson's disease. The book is divided into two parts: the first comprises chapters on normal sleep-wake homeostasis, followed by changes that occur in PD and discussions of available tools for the assessment of sleep-wake cycles in PD. In the second part, sleep and circadian disorders associated with PD are described in individual chapters, including sections on epidemiology, etiology, pathogenesis, differential diagnosis, and treatment. Click here for more details For more books concerning Parkinson's Disease go to Parkinson's Disease books In order to refer to this article on its own click here

 

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