PARKINSON'S DISEASE NEWS
29th July 2014 - New research
DISCOVERY OF NEW PARKINSON'S DISEASE GENETIC FACTORS
Nature Genetics  (27 July) (M.A.Nalls, N.Pankratz, C.M.Lill,
C.B.Do, D.G. Hernandez, M.Saad, A.L.De Stefano, E.Kara, J.Bras, M.Sharma,
C.Schulte, M.F.Keller, S.Arepalli, C.Letson, C.Edsall, H.Stefansson, X.Liu,
H.Pliner, J.H.Lee, R.Cheng, et al)
They conducted an extensive analysis of Parkinson's Disease genetic studies. Twenty six sites were identified as having a significant genetic association with Parkinson's Disease. These and six additional sites that had previously not been reported were then tested. In total, they identified and replicated 28 independent risk variants for Parkinson's disease across 24 loci (positions on the gene). Although the effect of each individual genetic risk was found to be small, a risk profile analysis showed that there was a substantial cumulative risk of developing Parkinson's Disease because of them. The risk was actually tripled when several genetic risk factors occurred simultaneously.
Their results suggested that the more variants a person has the greater the risk, which is up to three times higher for developing Parkinson's Disease in some cases. Genetic causes of Parkinson's Disease usually make Parkinson's Disease more likely rather than inevitable. Although genetic causes of Parkinson's Disease are uncommon the actual prevalence is unknown. In order to refer to this article on its own click here
27th July 2014 - New research
NASAL DELIVERY OF PARKINSON'S DISEASE TREATMENT
Expert opinion on drug delivery  11 (6) : 827-842 (S.Md, S.Haque, M.Fazil, M. Kumar, S.Baboota, J.K.Sahni, J.Ali) Complete abstract
Researchers evaluated whether prepared nanoparticles would be able to target Parkinson's Disease treatments to the brain via the nasal route, thereby enhancing their bioavailability. They tested the method using an optimised nanoformulation of the dopamine agonist bromocriptine for direct nose-to-brain delivery.
The percentage accuracy observed for intra-day and inter-day batch samples was very high. Bromocriptine was found to be stable in all exposed conditions. Bromocriptine nanoparticles also showed greater retention into the nostrils for about four hours. Direct bromocriptine nanoparticle nose-to-brain transport was shown to then bypass the blood-brain barrier. Most importantly, bromocriptine nanoparticles administered nasally showed significantly high dopamine concentrations.
The researchers concluded that Nanoparticle drug delivery system could be potentially used as a nose-to-brain drug delivery carrier for improving the existing means of treating Parkinson's Disease. In order to refer to this article on its own click here
23rd July 2014 - News release
APOMORPHINE CLINICAL TRIAL FOR PARKINSON'S DISEASE
CTH-105 is a Phase 2 clinical study of APL-130277. APL-130277 will be studied in 16 people with Parkinson's disease who have not used apomorphine and who experience at least one daily "off" episode, with a total duration of "off" in any 24-hour period of at least 2 hours. This open study will examine the effect of APL-130277 on relieving "off" episodes over a single day, with dose-titration used to determine dose strengths necessary for future clinical use.
In particular, the dose strength information is necessary in order to conduct the larger CTH-300a efficacy study in apomorphine naive patients, which is expected to commence at the end of 2014. The primary means of assessment will be the change in the UPDRS III score, which is the most widely used Parkinson's Disease symptom questionnaire. For more information go to Cynapsus In order to refer to this article on its own click here
17th July 2014 - New research
SOCIAL PHOBIAS ARE COMMON IN PARKINSON'S DISEASE
14th July 2014 - New research
MISDIAGNOSIS OF PARKINSON'S DISEASE
Researchers aimed to determine the diagnostic accuracy of a clinical
diagnosis of Parkinson's Disease using neuropathologic diagnosis as the
standard. The accuracy of diagnosis was found to be very poor.
neuropathologic findings of Parkinson's Disease as the standard, this study
established a finding of only 26% accuracy for a clinical diagnosis of
Parkinson's Disease in untreated patients, 53% accuracy in early Parkinson's
Disease of less than five years duration that was responsive to medication,
and 85% diagnostic accuracy in Parkinson's Disease of longer duration that
was medication-responsive. Clinical variables that improved diagnostic
accuracy were medication response, motor fluctuations, dyskinesias, and
hyposmia (reduced sense of smell).ic accuracy in Parkinson's Disease of
longer duration that was medication-responsive.
This study showed that a clinical diagnosis of Parkinson's Disease identifies people who will have pathologically confirmed Parkinson's Disease with a sensitivity of 88% and specificity of 68%. For more information concerning the diagnosis of Parkinson's Disease go to Diagnosis of Parkinson's Disease In order to refer to this article on its own click here
10th July 2014 - New research
ß-ASARONE INCREASES L-DOPA IN PARKINSON'S DISEASE
In order to increase the effect of L-dopa it is usually administered in combination with a dopa decarboxylase inhibitor. In Sinemet, L-dopa is combined with carbidopa. In Madopar, L-dopa is combined with benserazide. The co-administration of ß-asarone and Levodopa is being developed as a means of improving the effect of L-dopa even further.
ß-asarone is found in the flowering plant acorus and also in asarum, which is known as wild ginger. For more information go to Ansarone
In animal studies the use of L-dopa in combination with ß-asarone was
compared to the use of existing methods of treating Parkinson's Disease.
Dopamine levels were found to increase in the brain (in the striatum) and in
blood plasma in response to ß-asarone. The co-administration of ß-asarone
and L-dopa could also increase the levels in blood plasma of tyrosine
hydroxylase, which is the enzyme responsible for the formation of L-dopa.
Altogether, ß-asarone was found to have an effect on converting L-dopa into
dopamine by modulating the activity of dopamine metabolism.
The mechanism of co-administration of ß-asarone and L-dopa is different from that of Sinemet and Madopar in the treatment of Parkinson's Disease. The co-administration of ß-asarone and L-dopa may be more beneficial to Parkinson's Disease treatment than the existing methods and so could eventually replace them. In order to refer to this article on its own click here
5th July 2014 - New research
THE WORLDWIDE PREVALENCE OF PARKINSON'S DISEASE
Researchers sought to synthesize studies on the prevalence of Parkinson's Disease to obtain an overall view of how the prevalence varies by age, gender, and geographic location. Geographic location was stratified by the following groups : Asia, Africa, South America, Europe / North America / Australia. Data were analyzed by age group, geographic location, and gender.
of worldwide data showed a rising prevalence of Parkinson's Disease with
age, with (per 100,000) : 41 in 40 to 49 year olds, 107 in 50 to 59 year
olds, 173 in 55 to 64 year olds, 428 in 60 to 69 year olds, 1087 in 70 to 79
year olds, and 1903 in those aged older than 80.A
significant difference was seen in prevalence geographically only for people
who were 70 to 79 years old, with a prevalence of 1601 (per 100,000) in
people in North America, Europe, and Australia, compared to only 646 (per
100,000) in people from Asia. Differences in prevalence according to gender
was found only for people who were 50 to 59 years old, with a prevalence of
41 in females and 134 in males.