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PARKINSON'S DISEASE NEWS

 

 

 

 

 

 

MARCH 2016

 

26th March 2016 - New research

ANTI-PSYCHOTICS DOUBLE MORTALITY RISK IN PARKINSON'S DISEASE

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As many as 60% of people with Parkinson's Disease experience psychosis, and so the use of anti-psychotics in Parkinson's Disease is common. The use of anti-psychotics has been found to more than double the risk of mortality in Parkinson's Disease.

Anti-psychotic use in Parkinson's Disease was associated with more than twice (2.35 times) the risk of death compared with non use of anti-psychotics. The risk was significantly higher for people who used typical rather than atypical anti-psychotics. Among the atypical anti-psychotics used the risk relative to non use of anti-psychotics in descending order were 2.79 for olanzapine, 2.46 for risperidone, and 2.16 for quetiapine. The researchers concluded that the use of anti-psychotics is associated with a significantly increased mortality risk in people with Parkinson's Disease.

This finding highlights the need for cautious use of anti-psychotic use in people with Parkinson's Disease including examining the role of non-pharmacologic strategies in managing psychosis in Parkinson's Disease, and that anti-psychotics that do not increase mortality need to be developed.

Reference : JAMA Neurology [2016] Mar 21 [Epub ahead of print] (D.Weintraub, C.Chiang, H.M.Kim, J.Wilkinson, C.Marras, B.Stanislawski, E.Mamikonyan, H.C.Kales) Complete abstract

The U.S. Food and Drug Administration has just announced that Nuplazid (pimavanserin), which is Acadia Pharmaceuticals drug to treat psychosis associated with Parkinson's disease, was effective enough to warrant approval. Nuplazid could be the first drug specifically approved in the United States for Parkinson's disease psychosis (PDP). However, pimavanserin was previously found to increase the mortality rate even more than those drugs in the present study.  Complete abstract  In order to refer to this article on its own click here

 

18th March 2016 - New research

MONITORING TECHNOLOGIES TO ASSESS PARKINSON'S DISEASE

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Researchers carried out a systematic review in order to (1) list, (2) compare and (3) classify technological-based devices used to measure motor function in people with Parkinson's Disease into three groups : wearable, non-wearable and hybrid devices. A systematic search of the PubMed database resulted in the inclusion of 168 studies.

These studies were grouped based on the type of device used. For each device they reviewed the availability, use, reliability, validity, and sensitivity to change. 73 devices were identified. Of these, 22 were wearable, 38 were non- wearable, and 13 were hybrid devices. In accordance with their classification, 9 devices were recommended, 34 were suggested, and 30 devices were classified as listed. Within the wearable devices group, those classified as recommended were the :

Mobility Lab System (APDM) - A watch-sized device consisting of up to six sensors that enables the registration of different outcomes such as, postural sway, lower limb gait,  postural transitions, upper limb gait, and trunk measures. Go to the web site

Physilog - An analysis method that uses body-attached gyroscopes to assess spatio-temporal parameters of gait, sway, physical activity, tremor and bradykinesia.Minimal attachment sites are used and no calibration is needed. Go to the web site

StepWatch 3 - The StepWatch 3 (SAM) is a step activity monitor used to capture differences in ambulatory activity according to age and functional limitation. The StepWatch (SAM) is the size of a pager and attaches to the ankle. Go to the web site

TriTrac RT3 Triaxial accelerometer - The TriTrac RT3 may be suitable for sustained tracking of free-living physical activity in the home environment. It is small, capable of collecting and storing data in one-minute epochs for 21 days. Go to the web site

McRoberts DynaPort - The DynaPort MiniMod Hybrid combines acceleration sensors and gyroscopes with six channels that assess the individual’s movement at 100Hz each. Go to the web site

Axivity (AX3) - The Axivity (AX3) is a three-axis accelerometer that has a non-volatile flash memory chip linked by a USB-enabled microcontroller. Inside the sealed polycarbonate puck is a temperature sensor, ambient light sensor, and real time clock and lithium polymer battery. Go to the web site

Within the non-wearable devices group, those classified as recommended :

Nintendo Wii Balance Board - Nintendo Wii Balance Board is a commonly used accessory for video game consoles. It is considered a cheap, widespread, clinimetric robust device that can be used to measure postural instability in PD patients. Go to the web site

GAITRite gait analysis system - The GAITRite system is an electronic pathway that contains pressure sensitive sensors arranged in a grid-like pattern. The carpet is portable and can be rolled up for transportation. It is used for laboratory evaluation and provides information regarding several gait parameters, such as walking speed, cadence and step length. Go to the web site

Within the hybrid devices group the only one classified as recommended  was the :

Kinesia system - Kinesia integrates accelerometers and gyroscopes in a compact patient-worn unit to capture kinematic movement disorder features. The sensor component of the device is mounted on a ring, which fits on a finger. Go to the web site

Reference : Journal of Neuroengineering and Rehabilitation [2016] 13 (1) : 24 (C.Godinho, J.Domingos, G.Cunha, A.T.Santos, R.M.Fernandes, D.Abreu, N.Gonçalves, H.Matthews, T.Isaacs, J.Duffen, A.Al-Jawad, F.Larsen, A.Serrano, P.Weber, A.Thoms, S.Sollinger, H. Graessner, W.Maetzler, J.J.Ferreira) Go to the Complete study In order to refer to this article on its own click here

 

16th March 2016 - New research

SMARTPHONES FOR ASSESSING PARKINSON'S DISEASE TREMOR

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The assessment of Parkinson's Disease and the treatments that sohould be used for it are dependent on the quantification of symptoms such as tremor. A new system has been proposed for mobile phone applications, in which the mobile phone assesses the level and frequency of a person's tremor. . The system is based on measuring the acceleration from the hand of the person with Parkinson's Disease using a mobile cell phone accelerometer. For more information concerning use of mobile phone accelerometers for tremor go to : Mobile phone accelerometers

Recordings were made from an equal number of people with and without Parkinson's Disease. The recordings were analysed using a two level wavelet packet analysis. Features were extracted forming a feature vector of 12 different elements. The features extracted from the subjects were classified using a neural networks classifier. The results obtained showed an accuracy of 95%. These results indicate that a cell phone accelerometer can accurately detect and record rest tremor in people with Parkinson's Disease.

Reference : Journal of Medical Engineering Technology [2016] Mar 15 : 1-8 [Epub ahead of print] (L.Fraiwan, R.Khnouf, A.R.Mashagbeh) Complete abstract  In order to refer to this article on its own click here

 

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