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FEBRUARY 2016

 

18th February 2016 - New research

IRON ACCUMULATION IN PARKINSON'S DISEASE

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Previous studies have claimed that there is an accumulation of iron in the brains of people with Parkinson's Disease This study was designed to explore the progressive pattern of iron accumulation at different stages of Parkinson's Disease. They were able to confirm a regionally progressive pattern of iron accumulation in the different stages of Parkinson's Disease.

The substantia nigra pars compacta, which is the primary area of the brain affected by Parkinson's Disease, showed significantly increased iron levels in people with early Parkinson's Disease. In people with advanced Parkinson's Disease, the regions of the brain with higher concentrations of iron spread to other areas of the brain (substantia nigra pars reticulata, red nucleus, globus pallidus).

Iron accumulation occurs in Hereditary Hemochromatosis. If iron accumulation caused Parkinson's Disease people with Hereditary Hemochromatosis should also have Parkinson's Disease. However, very few people with Hereditary Hemochromatosis have it. Instead of causing Parkinson's Disease, higher intake of iron is associated with a reduced risk of Parkinson's Disease. Iron is essential for the formation of dopamine, which is deficient in Parkinson's Disease. It is a common compensatory mechanism for a cofactor such as iron to accumulate when the substance it facilitates the formation of is deficient. So instead of iron accumulation causing Parkinson's Disease, Parkinson's Disease causes iron accumulation.

Reference : NMR in Biomedicine [2016] Feb 8 [Epub ahead of print] (X.Guan, M.Xuan, Q.Gu, P.Huang, C.Liu, N.Wang, X.Xu, W.Luo, M.Zhang) Complete abstract  In order to refer to this article on its own click here

 

11th February 2016 - New research

EXCESSIVE DAYTIME SLEEPINESS IN PARKINSON'S DISEASE

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Excessive daytime sleepiness (EDS) is a common feature of Parkinson's disease (PD) that contributes to the disease burden and increases the risk of harm. For more information go to : Excessive daytime sleepiness  The aim of this study was to examine persistency and risk factors for EDS in people with Parkinson's Disease.

Excessive daytime sleepiness proved to be a non-persistent symptom in Parkinson's Disease, although persistency and the proportion of patients with EDS increased when followed up. At the outset, 43% of people with Parkinson's Disease had EDS. This increased to 46% when checked later on. Those factors that were more associated with Excessive daytime sleepiness in Parkinson's Disease were : male gender, poorer night time sleep, cognitive dysfunction, autonomic dysfunction, hallucinations, less severe dyskinesias, dosage of dopamine agonists, and use of anti-hypertensives.

With longer disease duration of Parkinson's Disease a large proportion of patients develop Excessive daytime sleepiness (EDS). However, some of the risk factors are modifiable, and so can be altered in order to lessen the degree of Excessive daytime sleepiness.

Reference : Parkinsonism and Related Disorders [2016] Jan 22 [Epub ahead of print] (KI. Zhu, J.J.van Hilten, J.Marinus)  Complete abstract  In order to refer to this article on its own click here

 

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